Synaptophysin Antikörper

Produktnummer ABIN1109182

Produktdetails anti-Synaptophysin Antikörper

Target: Synaptophysin (SYP)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Synaptophysin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Anti-Synaptophysin reacts with neuroendocrine cells of Human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa. Positive staining is seen in neurons of the brain, spinal cord, retina, and Paneth's cells in the gastrointestinal tract and gastric parietal cells. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Anti-Synaptophysin is an independent broad-range marker of neural and neuroendocrine differentiation.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Purified

Klon: MRQ-40

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.09 % Sodium Azide, 0.9 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Synaptophysin

Target: Synaptophysin (SYP)

Andere Bezeichnung: Synaptophysin / SYP (SYP Produkte)

Synonyme: syp-B antikoerper, xsypii antikoerper, MGC86267 antikoerper, MRXSYP antikoerper, A230093K24Rik antikoerper, AI848995 antikoerper, Syn antikoerper, p38 antikoerper, Syp1 antikoerper, mrxsyp antikoerper, syp antikoerper, xsypi antikoerper, synaptophysin S homeolog antikoerper, synaptophysin antikoerper, synaptophysin L homeolog antikoerper, synaptophysin a antikoerper, syp.S antikoerper, SYP antikoerper, syp antikoerper, Syp antikoerper, syp.L antikoerper, sypa antikoerper

Hintergrund: Synaptophysin is a synaptic vesicle glycoprotein with 4 transmembrane domain MW 38 kDa. Thisproteinis present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is also marker of endocrine tumors. It is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker

Gen-ID: 6855

NCBI Accession: NP_003170

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity