SNAP25 Antikörper (C-Term)

Produktnummer ABIN1109085

Produktdetails anti-SNAP25 Antikörper

Target: SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNAP25 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects SNAP25 (C-term). No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, rat

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human SNAP25 .Remarks: The sequence is identical to the related rat and mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu SNAP25

Target: SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))

Andere Bezeichnung: SNAP25 (SNAP25 Produkte)

Synonyme: RIC-4 antikoerper, RIC4 antikoerper, SEC9 antikoerper, SNAP antikoerper, SNAP-25 antikoerper, bA416N4.2 antikoerper, dJ1068F16.2 antikoerper, SNAP-25B antikoerper, SNAP-25a antikoerper, ric-4 antikoerper, ric4 antikoerper, sec9 antikoerper, snap-25 antikoerper, Bdr antikoerper, sp antikoerper, fj55h11 antikoerper, snap25 antikoerper, wu:fj55h11 antikoerper, Snap antikoerper, snap25.2 antikoerper, wu:fj33h05 antikoerper, synaptosome associated protein 25 antikoerper, synaptosome associated protein 25kDa S homeolog antikoerper, synaptosomal-associated protein, 25kDa antikoerper, synaptosomal-associated protein 25 antikoerper, synaptosome associated protein 25kDa antikoerper, synaptosome associated protein 25kDa L homeolog antikoerper, zgc:101731 antikoerper, synaptosomal-associated protein, 25b antikoerper, SNAP25 antikoerper, Snap25 antikoerper, snap25.S antikoerper, snap25 antikoerper, BACOIKO003_07 antikoerper, Tsp_10811 antikoerper, snap25.L antikoerper, zgc:101731 antikoerper, snap25b antikoerper

Hintergrund: Synaptosome-associated protein of 25,000 daltons also known as SNAP-25 is a protein which in humans encodes a 25-kD protein of 206 amino acids. It was first investigated as a neuron-specific gene preferentially expressed in mouse hippocampus. The tSNARE (the target-membrane soluble NSFattachment protein receptor, where NSF is N-ethylmaleimide-sensitive fusion protein) synaptosomalassociated protein of 25 kDa (SNAP-25) is expressed in pancreatic B-cells and its cleavage by botulinum neurotoxin E (BoNT/E) abolishes stimulated secretion of insulin. In the nervous system, two SNAP-25 isoforms (a and b) have been described, which are produced by alternative splicing. Nagy et al. (2004) identified mammalian Snap25a and Snap25b as targets of protein kinase A, a key regulator of neurosecretion that primes slowly releasable pools and readily releasable pools of secretory vesicles. SNAP-25 inhibits P/Q-and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP-25 decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.Synonyms: RIC4, SNAP, SNAP-25, SUP, Super Protein, Synaptosomal-associated 25 kDa protein, Synaptosomal-associated protein 25, ric-4

Gen-ID: 6616

NCBI Accession: NP_003072

UniProt: P60880

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport