Shigatoxin 1 Antikörper

Produktnummer ABIN1109003

Produktdetails

Target: Shigatoxin 1

Reaktivität: E. coli

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Functional Studies (Func), Enzyme Immunoassay (EIA)

Spezifität: The monoclonal antibody 13C4 recognizes the 1B subunit of Shiga-like toxin 1.

Aufreinigung: Protein G purified

Klon: 13C4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 2-8 °C.

Antigendetails

Target: Shigatoxin 1

Substanzklasse: Chemical

Hintergrund: Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share >99?% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60?% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct.The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.Synonyms: SLT-1 B subunit, SLT-1b, SLT-Ib, Verocytotoxin 1 subunit B, Verotoxin 1 subunit B, sltB, stxB

Gen-ID: 916677

NCBI Accession: NP_288672

UniProt: Q7DH26