Muscarinic Acetylcholine Receptor M2 Antikörper (C-Term)

Produktnummer ABIN1108326

Produktdetails anti-Muscarinic Acetylcholine Receptor M2 Antikörper

Target: Muscarinic Acetylcholine Receptor M2 (CHRM2) (Cholinergic Receptor, Muscarinic 2 (CHRM2))

Bindungsspezifität: AA 451-466, C-Term

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Muscarinic Acetylcholine Receptor M2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibopdy detects Muscarinic acetylcholine receptor M2 (C-term). It shows no cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Rat

Aufreinigung: Immunogen affinity chromatography

Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of human CHRM2 (451-466aa), identical to the related rat sequence

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu Muscarinic Acetylcholine Receptor M2

Target: Muscarinic Acetylcholine Receptor M2 (CHRM2) (Cholinergic Receptor, Muscarinic 2 (CHRM2))

Andere Bezeichnung: Muscarinic Acetylcholine Receptor M2 (CHRM2 Produkte)

Synonyme: HM2 antikoerper, AChR-M2 antikoerper, Chrm-2 antikoerper, M2 antikoerper, chrm2 antikoerper, Acm2 antikoerper, GPM2 antikoerper, cholinergic receptor muscarinic 2 antikoerper, cholinergic receptor, muscarinic 2, cardiac antikoerper, cholinergic receptor, muscarinic 2a antikoerper, cholinergic receptor, muscarinic 2 antikoerper, CHRM2 antikoerper, Chrm2 antikoerper, chrm2a antikoerper

Hintergrund: The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor. The M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system, by slowing the speed of depolarization. The CHRM2 gene inhibits the release of acetylcholine from cholinergic fibers in the lungs and elsewhere. In airway parasympathetic neurons, it is decreased by viral infections and by interferon-gamma, increasing actylcholine release. This gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, Gosso MF et al. genotyped three single-nucleotide polymorphisms (SNPs) in the CHRM2 gene on 7q31-35. CHRM2 is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders.Synonyms: CHRM2, mAChR M2, mAChR-M2

Gen-ID: 81645

NCBI Accession: NP_112278

UniProt: P10980