GJB2 Antikörper (Middle Region)

Produktnummer ABIN1107369

Produktdetails anti-GJB2 Antikörper

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GJB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody detects GJB2 / Cx26 (mid region). No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Immunogen affinity purified

Immunogen: Peptide mapping at the middle region of rat Connexin 26 .Remarks: Sequence is different from the relative sequence of human by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.

Buffer: 50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu GJB2

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Andere Bezeichnung: GJB2 / Cx26 (GJB2 Produkte)

Synonyme: ppk antikoerper, cx26 antikoerper, dfna3 antikoerper, dfnb1 antikoerper, nsrd1 antikoerper, dfna3a antikoerper, dfnb1a antikoerper, MGC53062 antikoerper, connexin-26 antikoerper, GJB2 antikoerper, AI325222 antikoerper, Cnx26 antikoerper, Cx26 antikoerper, Gjb-2 antikoerper, CXN-26 antikoerper, CX26 antikoerper, DFNA3 antikoerper, DFNA3A antikoerper, DFNB1 antikoerper, DFNB1A antikoerper, HID antikoerper, KID antikoerper, NSRD1 antikoerper, PPK antikoerper, gap junction protein beta 2 L homeolog antikoerper, gap junction protein beta 2 antikoerper, gap junction protein, beta 2 antikoerper, gjb2.L antikoerper, GJB2 antikoerper, Gjb2 antikoerper

Hintergrund: Connexin26(CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins,called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5 % identity with rat Cx26. connexin 26 (GJB2) is assigned to human chromosome 13q11-q12. Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.Synonyms: Connexin-26, Gap junction beta-2 protein

Gen-ID: 2706

NCBI Accession: NP_003995

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization