CD68 Antikörper

Produktnummer ABIN1106532

Produktdetails anti-CD68 Antikörper

Target: CD68 (CD68 Molecule (CD68))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD68 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This Monoclonal Antibody ED1 is useful for detecting Rat monocytes and macrophages and isolated dendritic (veiled) cells in the blood. The antibody recognises a single chain glycoprotein of 90-100 kDa. Weak cell surface expression also occurs. The antigen is expressed by the majority of tissue macrophages and weakly by peripheral blood granulocytes. Studies have shown that the antigen recognised by ED1 has many characteristics in common with Mouse macrosialin and Human CD68. Antigen, Epitope: CD68, ED1 recognises a 92 kDa cytoplasmic protein. The epitope has not been further characterized. Antigen Distribution: The antigen is found on 90 % of monocytes in the peripheral blood. It is also expressed by 98 % of isolated dendritic (veiled) cells.

Kreuzreaktivität (Details): Species reactivity (tested):Rat: Monocytes Macrophages, Dendritic Cells.

Aufreinigung: Affinity Chromatography

Klon: ED1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu CD68

Target: CD68 (CD68 Molecule (CD68))

Andere Bezeichnung: CD68 (CD68 Produkte)

Synonyme: Lamp4 antikoerper, Scard1 antikoerper, gp110 antikoerper, GP110 antikoerper, LAMP4 antikoerper, SCARD1 antikoerper, CD68 molecule antikoerper, CD68 antigen antikoerper, Cd68 molecule antikoerper, CD68 antikoerper, Cd68 antikoerper

Hintergrund: The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.Synonyms: Gp110, Macrophage marker, Macrosialin

Gen-ID: 287435