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CXCR4 Antikörper
CXCR4
Reaktivität: Human
FACS
Wirt: Maus
Monoclonal
B-R24
unconjugated
Produktnummer ABIN1105966
Produktdetails anti-CXCR4 Antikörper
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Target
Alle CXCR4 Antikörper anzeigen
CXCR4
(Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
Reaktivität
Alle Reaktivitäten für CXCR4 Antikörper
Human
Wirt
Alle Wirte für CXCR4 Antikörper
Maus
Klonalität
Alle Klonalitäten für CXCR4 Antikörper
Monoklonal
Konjugat
Alle Konjugate für CXCR4 Antikörper
Dieser CXCR4 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für CXCR4 Antikörper
Flow Cytometry (FACS)
Spezifität
Recognizes the soluble antigen. Recognizes the CXCR4 antigen, a 39.7 kDa protein.
Kreuzreaktivität (Details)
Species reactivity (tested):Human.
Aufreinigung
Ion Exchange Chromatography.
Immunogen
CXCR4 transfected CHO cell line. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Klon
B-R24
Isotyp
IgG1
Top Product
Discover our top product CXCR4 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
PBS containing 1 % BSA as stabilizer and 0.09 % Sodium Azide as preservative
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C.
Details zu CXCR4
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Target
CXCR4
(Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
Andere Bezeichnung
CD184 / CXCR4 (CXCR4 Produkte )
Synonyme
CD184 antikoerper, D2S201E antikoerper, FB22 antikoerper, HM89 antikoerper, HSY3RR antikoerper, LAP3 antikoerper, LCR1 antikoerper, LESTR antikoerper, NPY3R antikoerper, NPYR antikoerper, NPYRL antikoerper, NPYY3R antikoerper, WHIM antikoerper, Cmkar4 antikoerper, PB-CKR antikoerper, PBSF/SDF-1 antikoerper, Sdf1r antikoerper, CXC-R4-B antikoerper, CXCR-4-B antikoerper, cd184 antikoerper, cxcr4 antikoerper, fb22 antikoerper, hm89 antikoerper, hsy3rr antikoerper, lap3 antikoerper, lcr1 antikoerper, lestr antikoerper, npy3r antikoerper, npyr antikoerper, npyrl antikoerper, npyy3r antikoerper, xcxcr4 antikoerper, CXC-R4 antikoerper, CXCR-4 antikoerper, d2s201e antikoerper, whim antikoerper, CXC-R4-A antikoerper, CXCR-4-A antikoerper, xCXCR4 antikoerper, CXCR4 antikoerper, cb403 antikoerper, zgc:109863 antikoerper, cb824 antikoerper, C-X-C motif chemokine receptor 4 antikoerper, chemokine (C-X-C motif) receptor 4 antikoerper, C-X-C motif chemokine receptor 4 S homeolog antikoerper, C-X-C chemokine receptor type 4 antikoerper, C-X-C motif chemokine receptor 4 L homeolog antikoerper, chemokine (C-X-C motif), receptor 4b antikoerper, chemokine (C-X-C motif) receptor 4a antikoerper, CXCR4 antikoerper, Cxcr4 antikoerper, cxcr4.S antikoerper, cxcr4 antikoerper, LOC100049444 antikoerper, cxcr4.L antikoerper, cxcr4b antikoerper, cxcr4a antikoerper
Hintergrund
CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T cell tropic strains of HIV1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual tropic strains of HIV1 and mediates CD4 independent infection by HIV2. The a chemokine SDF1 is the ligand for CXCR4 and prevents infection by T tropic HIV1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV1 and HIV2 fusion and infection of human target cells. The amino terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites. CXCR4 is highly expressed in brain and heart, and in white blood cells, vascular endothelial cells, and umbilical cord endothelial cells.Synonyms: C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, NPYRL, SDF1 receptor, Stromal cell-derived factor 1 receptor
Gen-ID
7852
NCBI Accession
NP_001008540
UniProt
P61073
Pathways
Regulation of Cell Size , CXCR4-mediated Signaling Events
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