SNCA Antikörper (AA 1-140)

Produktnummer ABIN1105338

Produktdetails anti-SNCA Antikörper

Target: SNCA (Synuclein, alpha (SNCA))

Bindungsspezifität: AA 1-140

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SNCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody recognizes the recombinant α-synuclein

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G affinity purified

Immunogen: Recombinant human alpha-synuclein (1-140 aa) expressed in E. coli

Klon: 4H11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.01 M PBS pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.

Details zu SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Andere Bezeichnung: alpha-Synuclein / SNCA (SNCA Produkte)

Synonyme: snca antikoerper, MGC64356 antikoerper, LOC619283 antikoerper, NACP antikoerper, alphaSYN antikoerper, PARK1 antikoerper, PARK4 antikoerper, PD1 antikoerper, synuclein alpha L homeolog antikoerper, alpha-synuclein antikoerper, synuclein alpha antikoerper, synuclein, alpha antikoerper, snca.L antikoerper, LOC619283 antikoerper, SNCA antikoerper, Snca antikoerper

Hintergrund: Alpha-Synuclein belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. Alpha-synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble Aβ into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and is also observed in senile plaques of Alzheimer's disease patients. Human α-synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1

Gen-ID: 6622

NCBI Accession: NP_000336

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity