AKAP12 Antikörper (C-Term)

Produktnummer ABIN1105270

Produktdetails anti-AKAP12 Antikörper

Target: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser AKAP12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This anrtibody is expected to recognize both reported isoforms of AKAP12.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide with sequence C-KQERESAKSELTES, from the C-Terminus of the protein sequence according to NP_005091.2, NP_653080.1. Genename: AKAP12

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu AKAP12

Target: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Andere Bezeichnung: AKAP12 (AKAP12 Produkte)

Synonyme: akap12 antikoerper, cb27 antikoerper, esr1 antikoerper, fb72g12 antikoerper, id:ibd1202 antikoerper, sb:cb27 antikoerper, si:ch73-192g21.1 antikoerper, wu:fb72g12 antikoerper, wu:fc21c03 antikoerper, AKAP12 antikoerper, AI317366 antikoerper, SSeCKS antikoerper, Srcs5 antikoerper, Tsga12 antikoerper, AKAP12A antikoerper, AKAP12B antikoerper, AKAP12G antikoerper, AKAP250 antikoerper, A kinase (PRKA) anchor protein 12b antikoerper, A-kinase anchoring protein 12 antikoerper, A kinase (PRKA) anchor protein (gravin) 12 antikoerper, akap12b antikoerper, AKAP12 antikoerper, Akap12 antikoerper

Hintergrund: Gravin (also known as A Kinase Anchor Protein 12, AKAP12) was cloned from a cDNA expression library screened with serum, from a myasthenia gravis patient. Antibodies to Gravin were found in 22 out of 72 myasthemia gravis patients and absent in sera of normal individuals. This protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, cultured fibroblasts and osteosarcoma cells and highly expressed in the brain. Gravin can bind kinases like PKA and PKC by different domains of the protein and can localize these kinases to specific domains in the cell. Upon differentiation of NT2 cells to neurons (NT2 N), Gravin expression is up regulated and enriched at the inner peripheral cortex in close proximity to the plasma membrane. In differentiated cells, gravin is co-localized with PKCbII, PKCa and PKA. Decreased binding of PKCa to gravin was found after activation of PKC.Synonyms: A-kinase anchor protein 12, A-kinase anchor protein 250 kDa, AKAP250, Gravin, Myasthenia gravis autoantigen, PRKA12

Molekulargewicht: 191 kDa (NP_005091.2) and 181 kDa (NP_653080.1).

Gen-ID: 9590

NCBI Accession: NP_005091

Pathways: cAMP Metabolic Process