ARHGEF18 Antikörper (AA 159-551) (Biotin)

Produktnummer ABIN1046044

Produktdetails anti-ARHGEF18 Antikörper (Biotin)

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Bindungsspezifität: AA 159-551

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGEF18 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Rho guanine nucleotide exchange factor 18 protein (159-551AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Other species are not tested. Please decide the specificity by homology

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ARHGEF18

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Andere Bezeichnung: ARHGEF18 (ARHGEF18 Produkte)

Synonyme: arhgef18 antikoerper, wu:fc21e04 antikoerper, wu:fj05f11 antikoerper, zgc:85686 antikoerper, P114-RhoGEF antikoerper, AI467246 antikoerper, D030053O22Rik antikoerper, rho/rac guanine nucleotide exchange factor (GEF) 18a antikoerper, Rho/Rac guanine nucleotide exchange factor (GEF) 18 antikoerper, Rho/Rac guanine nucleotide exchange factor 18 antikoerper, rho guanine nucleotide exchange factor 18 antikoerper, rho/rac guanine nucleotide exchange factor (GEF) 18 antikoerper, arhgef18a antikoerper, ARHGEF18 antikoerper, LOC100027283 antikoerper, Arhgef18 antikoerper

Hintergrund:

Background: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). p114RgoGEF cts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. It may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS), but does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.

Aliases: 114 kDa Rho specific guanine nucleotide exchange factor antibody, 114 kDa Rho-specific guanine nucleotide exchange factor antibody, ARHGEF 18 antibody, Arhgef18 antibody, ARHGI_HUMAN antibody, KIAA0521 antibody, MGC15913 antibody, p114 Rho GEF antibody, p114-Rho-GEF antibody, p114RhoGEF antibody, Rho guanine nucleotide exchange factor 18 antibody, Rho specific guanine nucleotide exchange factor p114 antibody, Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody, Rho/Rac guanine nucleotide exchange factor 18 antibody, SA RhoGEF antibody, SA-RhoGEF antibody, Septin associated RhoGEF antibody, Septin-associated RhoGEF antibody

UniProt: Q6ZSZ5

Pathways: Neurotrophin Signalübertragung