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SREBP1 trans-activates CYP24A1 (zeige CYP24A1 Proteine) expression through SREBP binding elements present in the promoter.
Berberine (BBR), an effective suppressor of SREBP1 and lipogenesis regulated through reactive oxygen species (ROS (zeige ROS1 Proteine))/AMPK (zeige PRKAA1 Proteine) pathway, selectively inhibited the growth of G-R nonsmall cell lung cancer cells and rheumatoid arthritis patiens but not that of normal cells
These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control inclear cell renal cell carcinoma (zeige MOK Proteine) tumorigenesis.
findings showed that PTEN inhibits HBV replication as well as HBV HCV co-replication. SREBP-1 is involved in HBV HCV replication inhibition by PTEN
FTO (zeige FTO Proteine) increased the lipid accumulation in hepatocytes by increasing nuclear translocation of SREBP1c and SREBP1c maturation, thus improving the transcriptional activity of lipid droplet-associated protein (zeige PLIN1 Proteine) CIDEC (zeige CIDEC Proteine).
common SNPs (rs62064119, rs2297508, rs11868035 and rs13306741) in the SREBP-1c gene were selected and genotyped in 593 Han patients with NAFLD and 593 healthy controls. No significant differences in genotype and allele frequencies of these four SNPs were found between cases and controls, suggesting that the SNPs are not associated with risk of NAFLD in the Chinese Han population.
Data suggests that expression of CYP4F2 is down-regulated in liver of mice with non-alcoholic fatty liver disease after high-fat/Western diet and in human hepatocyte cell line exposed to excess palmitic acid, oleic acid, or fructose. Two other genes are down-regulated, PPAR gamma (zeige PPARG Proteine) and SREBP-1. (CYP4F2 = cytochrome P450 family 4 subfamily F member 2; PPAR (zeige PPARA Proteine) = peroxisome proliferator-activated receptor (zeige PPARD Proteine) )
LncARSR promotes hepatic lipogenesis via Akt (zeige AKT1 Proteine)/SREBP-1c pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis.
CpG sites located in SREBF2 (zeige SREBF2 Proteine) gene showed differential methylation in association with lipid traits. The expression of SREBF1 gene was inversely associated with methylation of its corresponding CpGs. Genetic variants in SREBF1 were also associated with lipid profile. SREBF1 expression was directly associated with HDL (zeige HSD11B1 Proteine) cholesterol.
Epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) signaling enhances miR (zeige MLXIP Proteine)-29 expression in glioblastoma cells via upregulation of Sterol regulatory element binding protein
Depletion of SREBP-1 had no impact on liver IRS1Y612, AktS473, and downstream effectors GSK3alphaS21 and FoxO1S256 during the fed state. Reduced levels of these molecules were observed under fasting conditions. The contribution of SREBP-1 to maintain insulin (zeige INS Proteine) signal transduction in liver is modest.
Data (including data from studies in transgenic/knockout mice) suggest that Kdm1a (zeige KDM1A Proteine)-mediated attenuation of Srebf1 (zeige TOM1L2 Proteine) transcriptional activities functions as underlying mechanism for suppression of de novo lipogenesis by oxidative stress in white adipose tissue. [Kdm1a (zeige KDM1A Proteine) = lysine (K)-specific demethylase-1A (zeige KDM1A Proteine); Srebf1 (zeige TOM1L2 Proteine) = sterol-regulatory element-binding transcription factor-1]
Tlr4 (zeige TLR4 Proteine)-mutant mice are resistant to acute alcohol-induced hepatic SREBP-1 activation and hepatic lipid accumulation.
Results showed that Glrx (zeige GRX1 Proteine)(-/-) mice exhibited decreased SirT1 (zeige SIRT1 Proteine) activity that leads to hyperacetylation and activation of SREBP-1 and upregulation of key hepatic enzymes involved in lipid synthesis.
Inhibition of NAMPT (zeige NAMPT Proteine) aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1 (zeige SIRT1 Proteine)/AMPKalpha (zeige GRK4 Proteine)/SREBP1 signaling pathway.
SREBP1 is dramatically reduced in dysbindin-1 (zeige DTNBP1 Proteine) knockout mice; possibly related to cognitive deficits.
Epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) signaling enhances miR (zeige MLXIP Proteine)-29 expression in glioblastoma cells via upregulation of Sterol regulatory element binding protein 1
The expression of hHL promoted hepatic triglyceride accumulation and de novo lipogenesis without affecting triglyceride secretion, and this was associated with an upregulation of Srebf1 (zeige TOM1L2 Proteine) as well as the main genes controlling the synthesis of fatty acids. Transgenic mice also exhibited more adiposity and an increased LPL (zeige LPL Proteine)-mediated FFA influx into the WAT without affecting glucose tolerance
Data show that miR (zeige MLXIP Proteine)-200b and miR (zeige MLXIP Proteine)-200c could directly bind the 3' UTR of JUN (zeige JUN Proteine), and JUN (zeige JUN Proteine) activated the transcription of srebp1 to increase lipid accumulation.
In vivo, the data of established transgenic animals showed that mice with lncHR1 expression had less hepatic expression of SREBP-1c, FAS (zeige FAS Proteine), Acetyl-CoA carboxylase alpha (zeige ACACA Proteine) (ACCalpha), and less hepatic and plasma TG after being fed a high-fat diet.
Polymorphisms of the ACACA (zeige ACACA Proteine) and SREBF1 genes are promising markers for pig carcass and performance traits.
Results of associated analysis show that the polymorphism of ADD1 gene was associated traits of Intramuscular fat content (IMF (zeige MDFI Proteine)) and back fat thickness (BF).
SREBF1 might play an important role in regulation of muscle fat deposition during postnatal growth of pigs.
Expression of SCD1 (zeige SCD Proteine) was downregulated through reduced transcription and abundance of the transcription factor sterol regulatory element-binding protein 1 (SREBP1c).This effect was augmented by local chromatin tightening and DNA methylation (zeige HELLS Proteine) at and around the SREBP1c binding site in the SCD1 (zeige SCD Proteine) promoter
SREBP1a activated while C/EBP (zeige CEBPA Proteine) factors downregulated the activity of the SCD1 (zeige SCD Proteine) promoter.
These results suggest that increased expression of hepatic CD36 (zeige CD36 Proteine) and SREBP-1 is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Hepatic SREBP-1c-mediated lipid synthesis and the NF-kappaB (zeige NFKB1 Proteine) inflammatory pathway were both overinduced in cows with fatty liver.
SREBP1 was found to be a key positive regulator of milk fat synthesis and was shown to be regulated by stearic acid and serum.
data suggest that low SREBP-1c expression can decrease lipid synthesis, increase lipid oxidation, and decrease the TG and VLDL content in bovine hepatocytes
84-bp indel in intron 5 was significantly associated with palmitoleic acid, stearic acid, saturated fatty acids, triglycerides and the C16 index in Simmental bulls.
genetic polymorphisms in sterol regulatory element binding transcription factor 1 (SREBF1)can be used to develop genetic tools for the selection of animals producing milk with healthier fatty acid composition
The results of this study demonstrated the existence of the polymorphisms in the SCD1 (zeige SCD Proteine) and SREBP-1 genes in the population of Fleckvieh cattle and their associations with the concentrations of several muscle fat and subscutaneous fat fatty acids.
These results provide detailed genetic information for the SREBP1 signalling pathway and SCD (zeige SCD Proteine) that can be used to change milk fat composition by marker-assisted breeding.
the ability of Pu-erh (zeige ERH Proteine) tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD (zeige SCD Proteine), thereby reducing fat storage.
SBP-1/SREBP-1 is part of a conserved feedback loop responding to phosphatidylcholine (zeige SGMS1 Proteine) levels to regulate expression of one-carbon cycle biogenesis genes and ensure adequate S-adenosylmethionine levels for phosphatidylcholine (zeige SGMS1 Proteine) production.
elo-5 and elo-6 may be transcriptional targets of LPD (zeige ACSBG1 Proteine)-1
both SBP-1 and MDT-15 control transcription of genes governing desaturation of stearic acid to oleic acid
Essential role of sbp-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
, class D basic helix-loop-helix protein 1
, sterol regulatory element-binding protein 1
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element binding protein 1
, adipocyte determination and differentiation-dependent factor 1
, sterol regulatory binding transcription factor 1
, sterol regulatory element-binding transcription factor 1
, sterol regulatory element binding-protein 1
, sterol regulatory element binding transcription factor 1
, sterol response element binding protein 1
, similar to sterol regulatory element binding transcription factor 1 isoform b
, sterol regulatory element binding protein-1
, sterol regulatory element-binding protein 1-like
, Sterol regulatory element Binding Protein family member (sbp-1)
, Sterol regulatory element-binding transcription factor 1