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Taken together, these results suggested that alpha1B-adrenoceptor signaling is required for bone formation and regulated cellular proliferation through a mechanism relevant to the up-regulation of CCAAT/enhancer-binding protein delta (zeige CEBPD Proteine) in osteoblasts and, thus, provide new evidence for the physiological importance of alpha1B-adrenoceptor signalling in bone homeostasis
eIF3f (zeige EIF3F Proteine)/alpha adrenergic receptor interaction
The adra1b mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium
in mouse ureters: the mRNA for the alpha1A-adrenoceptor was more prevalent than those for the alpha1B- and alpha1D-adrenoceptors
Overexpression of the alpha(1B (zeige CACNA1B Proteine))-AR in mice can cause a synucleinopathy with excessive tyrosine nitration but decreased phoshorylation similar to parkinsonian syndromes
alpha(1)-ARs (zeige SLURP1 Proteine) in male mice are required for the physiological hypertrophy of normal postnatal cardiac development and for an adaptive response to cardiac stress
alpha(1A)- and alpha(1B (zeige CACNA1B Proteine))-adrenoceptors have roles in myocardial contractions
ADRA1b has a role in regulating glucose homeostasis in mice
These results demonstrate a critical role for the alpha(1B (zeige CACNA1B Proteine))AR in baroreceptor-mediated adrenergic signaling at the vascular neuroeffector junction. Moreover, alpha(1B (zeige CACNA1B Proteine))ARs (zeige SLURP1 Proteine) modulate inotropic responses to baroreceptor activation.
alpha1B-ARs (zeige SLURP1 Proteine) are the major alpha1-AR subtype expressed in DU145, PC3 (zeige BTG2 Proteine), and all TRAMP (zeige DPT Proteine) cell lines, but most of the receptor is localized in intracellular compartments in a nonfunctional state, which can be rescued upon prolonged incubation with any ligand.
Hetero-oligomerization of a1B (zeige A1BG Proteine)/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4 (zeige CXCR4 Proteine):atypical chemokine receptor 3 heteromeric complex is required for a1B (zeige A1BG Proteine)/Dadrenergic receptor function.
ADRA1B rs10070745 was significantly associated with vasoconstrictor responses.
Receptor Species-dependent Desensitization Controls KCNQ1 (zeige KCNQ1 Proteine)/KCNE1 (zeige KCNE1 Proteine) K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.(
protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein-mediated signaling turn-off.
alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1 (zeige TGFB1 Proteine), IGF-1 (zeige IGF1 Proteine), hyaluronan and PIP (zeige PIP Proteine) production in human skin fibroblasts.
heteromeric receptor complexes between alpha1A-AR and CXCR4 (zeige CXCR4 Proteine) and between alpha1B-AR and CXCR4 (zeige CXCR4 Proteine) are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction
alpha1B-AR signals through calcium, ERK1/2 and p38 (zeige CRK Proteine) only when located in the membrane and the signals disappear by membrane disruption.
A rare ADRA1B haplotype composed of six single nucleotide polymorphism(SNP)s is associated with attention deficit hyperactivity disorder (ADHD).
Noradrenaline facilitated cell proliferation by regulation of potassium currents in human osteoblasts via G(i/o) -protein-coupled alpha(1B (zeige CACNA1B Proteine)) -adrenoceptors, not via coupling to Gq-proteins
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.
, adrenergic, alpha-1B-, receptor
, alpha-1B adrenergic receptor-like
, alpha-1B adrenergic receptor
, alpha-1B adrenoreceptor
, alpha1B-adrenergic receptor
, alpha-1B-adrenergic receptor
, Adrenergic alpha 1B- receptor
, adrenergic receptor, alpha 1b
, alpha 1B-adrenoceptor
, alpha 1B-adrenoreceptor
, alpha 1b adrenoceptor