alpha-conotoxin IMI (alpha conotoxin IMI)
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- Target
- alpha-conotoxin IMI
- Applikation
- Blocking Reagent (BR)
- Verwendungszweck
- alpha-conotoxin IMI blocks nAChR
- Sequenz
- Gly-Cys2-Cys3-Ser-Asp-Pro-Arg-Cys8-Ala-Trp-Arg-Cys12-NH2Disulfide bonds between Cys2-Cys8 and Cys3-Cys12
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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-
- Target
- alpha-conotoxin IMI
- Hintergrund
- Alpha-conotoxin IMI has been isolated from the venom of the cone snail Conus mperialis. alpha-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). This toxin blocks mammalian neuronal nAChRs (alpha3/ß2 > alpha7 > alpha3/ß4). It has no effect on nAChRs composed of alpha2/ß2, alpha3/ß2, alpha4/ß2, alpha2/ß4, alpha3/ß4, or alpha4/ß4 subunits. alpha-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.
- Molekulargewicht
- 1352.92 Da
- CAS-Nummer
- 156467-85-5
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