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The protein encoded by SERPINF1 is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. Zusätzlich bieten wir Ihnen serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Kits (83) und serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Proteine (56) und viele weitere Produktgruppen zu diesem Protein an.
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Expression of GLUT1 (zeige SLC2A1 Antikörper) is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 (zeige SLC2A1 Antikörper) in the cell membrane that contributes to the impairment of the RPE (zeige RPE Antikörper) secretory function of PEDF.
Serum levels of PEDF were significantly correlated with body mass index, vasodilation and brachial artery intima-media thickness.
PEDF expression in retinal endothelial cells plays a key role in modulation of cell proliferation, migration, and capillary morphogenesis.
study found that PEDF binds to the C1q head regions and activates the classical complement pathway; in addition, observed that in synovial fluid (SF) from rheumatoid arthritis patients, PEDF forms detectable complexes with C4d, which are present in a range of concentrations; SF from nonarthritic donors consistently contained little or no C4d-PEDF complexes
PEDF is a hormone-regulated negative autocrine mediator of endometrial proliferation.
Findings suggest that PEDF plays a critical role in preventing hypoxia/reoxygenation injury by modulating anti-oxidant and anti-apoptotic factors and promoting autophagy.
PEDF is associated with increased epithelial-mesenchymal transition in bladder cancer
Six rare heterozygous SERPINF1 variants were found in seven patients in our familial otosclerosis cohort; three are missense mutations predicted to be deleterious to protein function
Excessive amount of PEDF50 in myopic specimens have been shown to correlate with the abrogated PEDF processing rather than with an increase of its expression. Moreover, immunohistochemical staining of the myopic Tenon's capsule tissue sections revealed the halo of deposited PEDF50 in the fibroblast extracellular space.
Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway may mediate ox-LDL-induced endothelial injury via oxidative stress, and PEDF ameliorates endothelial injury by suppressing Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway and subsequently reducing oxidative stress.
After cryotherapy of the sclera, pigment epithelium-derived factor levels increased 44.8% compared to untreated controlsand stayed at that level until day 14. It returned to baseline by day 21. (untreated).
the inhibitory effect of PEDF appears to be mediated via the processing of VEGF-R2 by gamma-secretase
PEDF inhibits key steps in the angiogenic response of retinal capillary endothelial cells, including cell proliferation and vascular tubule formation. Gene expression of PEDF is negatively regulated by glucose, insulin (via mTOR) and VEGF.
Results suggest that leptin (zeige LEP Antikörper) might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes.
PEDF promotes growth of pericytes through autocrine production of PDGFB.
PEDF and VEGFR-1 (zeige FLT1 Antikörper) have roles in the negative regulation of angiogenesis
data suggest that PEDF, via its potent antiangiogenic capabilities, may contribute to superior healing in wounds on the trunks of horses by protecting from excessive formation of vascular granulation tissue
Combination of neuroprotective factors Pedf plus docosahexaenoic acid (DHA) stimulates corneal nerve regeneration. Data suggest activation of Pedfr by Pedf (here, applied topically to treat corneal nerve injury) promotes regeneration of corneal nerve via up-regulation of release of DHA (here, also applied topically) and expression of specific nerve tissue/eye proteins. (Pedfr = pigment epithelium-derived factor receptor)
The renoprotective effects of PEDF are mediated, at least partially, by inhibition of the Wnt (zeige WNT2 Antikörper) pathway in kidneys.
PEDF deficiency has a significant impact on retinal endothelial cell adhesion and migration through altered production of extracellular matrix and junctional proteins in response to increased oxidative stress affecting their proangiogenic activity.
These results indicate that PEDF counters Wnt (zeige WNT2 Antikörper) signaling to allow for osteoblast differentiation and provides a mechanistic insight into how the PEDF null state results in OI type VI.
Furthermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a (zeige WNT3A Antikörper)-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (zeige SOD2 Antikörper)) and catalase (zeige CAT Antikörper).
Study demonstrated the inhibitory effect of PEDF on insulin (zeige INS Antikörper)-dependent molecular mechanisms of glucose homeostasis, and suggests that PEDF could be a specific target in the management of metabolic disorders.
Alpha-2-Antiplasmin (zeige Alpha2 Antiplasmin Antikörper) mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction via induction of TGF-beta (zeige TGFB1 Antikörper).
PEDF inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids in diabetic retinopathy.
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.
cell proliferation-inducing gene 35 protein
, pigment epithelium-derived factor
, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
, serpin F1
, alpha-2 antiplasmin
, pigment epithelium derived factor
, serpin peptidase inhibitor, clade F, member 1
, serine (or cysteine) proteinase inhibitor, clade F), member 1
, serine (or cysteine) proteinase inhibitor, clade F, member 1
, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
, alpha-2 antiplasmin, pigment epithelium derived factor
, pigment epithelium-derived factor-like
, stromal cell derived factor 3
, stromal cell-derived factor 3
, serine (or cysteine) peptidase inhibitor, clade F, member 1