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GABRA1 encodes a gamma-aminobutyric acid (GABA) receptor. Zusätzlich bieten wir Ihnen gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 Antikörper (180) und viele weitere Produktgruppen zu diesem Protein an.
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Human GABRA1 Protein expressed in Wheat germ - ABIN1354645
Di, Wang, Han, Fu, Duerfeldt, Blagg, Mu: Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation. in The Journal of biological chemistry 2016
Rs2279020 (GABRA1, G > A) variation was associated with a decreased risk of developing VPA-resistant epilepsy.
The results further substantiate the role of GABRA1 in phenytoin mode of action in epilepsy.
Our study findings showed COMT (zeige COMT Proteine) polymorphism conferring risk and GABRA1 and GABRA2 (zeige GABRA2 Proteine) polymorphism as a protective genotype for Indian male with alcohol dependence (AD)
The polymorphism of rs1129647 and rs2290733 of GABRA1 has a nominal relationship with amphetamine-induced psychotic disorder .
Study confirms GABRA1 mutations as significant contributors to the genetic etiology of both mild and severe epilepsy syndromes. GABRA1 mutations, through a possible mechanism of haploinsufficiency, cause an impairment of the GABA inhibitory function leading to a wide spectrum of epilepsy phenotypes.
This unique case not only allows to further define the phenotypic spectrum of infantile epileptic encephalopathy associated with rare de novo GABRA1 variants but exemplifies the need for a sensitive review of unclear associations in clinically defined syndromes and for extended diagnostic work-up in individuals with unusual presentations of a genetically confirmed diagnosis.
This study clarifies a Grp94 (zeige HSP90B1 Proteine)-mediated ERAD pathway for GABAA (zeige GABRg1 Proteine) receptors, which provides a novel way to finely tune their function in physiological and pathophysiological conditions.
GABRA1 missense mutations were linked to early onset epileptic encephalopathies, including Ohtahara syndrome and West syndrome.
Polymorphism rs4263535 in GABRA1 intron 4 was associated with deeper sedation by intravenous midazolam.
Putative GABAA (zeige GABRg1 Proteine) and ASIC1a (zeige ACCN2 Proteine) channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
GAPDH (zeige GAPDH Proteine) directly phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at identified serine and threonine residues. GAPDH (zeige GAPDH Proteine) and the alpha1 subunit were found to be colocalized at the neuronal plasma membrane.
Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA (zeige GABRg1 Proteine)) receptors
We used a low-affinity antagonist to show that GABAA (zeige GABRg1 Proteine)-receptor saturation occurs at this synapse but does not underlie frequency-invariant transmission.
This study suggests that movement of loop G in the beta1 strand of the GABAA (zeige GABRg1 Proteine) receptor alpha1 subunit is involved in a conformational rearrangement associated with channel activation
These data suggest that GABA, acting through both presynaptic GABAA (zeige GABRg1 Proteine) and GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result not possible from activation of either receptor type alone
Nbea targets glutamate (zeige GRIN1 Proteine) and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins.
the identity and location of distinct GABAAR (zeige GABRG2 Proteine) subunits within the cellular networks of the mouse dorsal raphe nucleus and that stress impacts on the expression levels of particular subunits at the gene and protein level
This study demonstrated that Adolescent-onset GABAA (zeige GABRg1 Proteine) alpha1 silencing regulates reward-related decision making in mice.
Enduring loss of tonic but not phasic GABAAR (zeige GABRG2 Proteine) currents critically contributes to the prolonged amygdala disinhibition subsequent to chronic stress.
these findings suggest that gephyrin (zeige GPHN Proteine) may be a key factor in BDNF (zeige BDNF Proteine)-dependent GABAAR (zeige GABRG2 Proteine) regulation in the amygdala.
Gabra1 receptors are expressed in the ventral thalamus in an absence epilepsy model.
The effects of heterozygous knock-out of GABAAR (zeige GABRG2 Proteine) alpha1 on the expression and physiology of GABAARs in the mouse cortex, were determined.
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.
GABA(A) receptor subunit alpha-1
, GABA(A) receptor, alpha 1
, gamma-aminobutyric acid receptor subunit alpha-1
, gamma-aminobutyric acid A receptor, alpha 1
, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1
, gamma-aminobutyric acid A receptor, alpha 1
, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
, GABAA alpha 1