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This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx).
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Absence of Xk was accompanied by changes in erythrocyte K(+), Mg(2+), Na(+) & Ca(2+) transport associated with changes in mean cellular volume & corpuscular hemoglobin concentration mean. Xk deletion blocked Na/Mg exchanger activity.
This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins.
membrane transport protein XK
, Kell blood group
, XK-related protein 1
, XK, Kell blood group complex subunit
, McLeod syndrome gene homolog
, XK homolog
, Kell blood group precursor (McLeod phenotype)
, Kx antigen
, XK, Kell blood group complex subunit (McLeod syndrome)
, kell complex 37 kDa component
, Kell blood group precursor (McLeod phenotype) homolog
, X-linked Kx blood group (McLeod syndrome) homolog
, X Kell blood group precursor-related family, member 1
, XK-related 1