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WNK3 encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal WNK3 Primary Antibody für IP, WB - ABIN315865
Haas, Cuddapah, Watkins, Rohn, Dy, Sontheimer: With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume. in American journal of physiology. Cell physiology 2011
Data show that WNK lysine deficient protein kinase 3 protein (WNK3) interacts with NCC (zeige SLC12A3 Antikörper) and increases the Na-Cl cotransporter (NCC (zeige SLC12A3 Antikörper)) expression on the cell membrane and in cytoplasm together.
WNK3 enhances NCC (zeige SLC12A3 Antikörper) protein expression by increasing NCC (zeige SLC12A3 Antikörper) synthesis via an ERK 1 (zeige MAPK3 Antikörper)/2-dependent signaling pathway
WNK3 knockout mice exhibited significantly decreased infarct volume in a transgenic model of stroke and brain damage.
There may be a novel role for WNK3 on the renal Na+-Cl-cotransporter (NCC (zeige SLC12A3 Antikörper)) expression at the plasma membrane, an effect apparently independent of the SPAK (zeige STK39 Antikörper) kinase and the aldosterone-SGK1 (zeige SGK1 Antikörper) pathway.
LINGO-1 (zeige LINGO1 Antikörper) potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.
WNK3 modulates intracellular Cl(-) concentration and regulatory volume decrease in HEK293 cells.
The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (zeige SLC12A2 Antikörper)/2 and NCC (zeige SLC12A3 Antikörper) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.
Analysis of the data showed that WNK3 is an essential regulator of NKCC1 (zeige SLC12A2 Antikörper) and that WNK3 activates NKCC1 (zeige SLC12A2 Antikörper)-mediated ion transport necessary for cell volume changes associated with cell invasion.
OXSR1 (zeige OXSR1 Antikörper) and WNK3 transcripts were substantially overexpressed in subjects with schizophrenia relative to comparison subjects.
Data find that expression of the N termini of all four WNKs results in modest to strong activation of SGK1 (zeige SGK1 Antikörper).
WNK3 knockout mice show faster neurological functional recovery after occlusion of the left middle cerebral artery.
angiotensin II activates the WNK-SPAK (zeige STK39 Antikörper)-NKCC1 (zeige SLC12A2 Antikörper) phosphorylation cascade through the angiotensin II type 1 receptor (zeige AGTR1 Antikörper). activation of the WNK-SPAK (zeige STK39 Antikörper)-NKCC1 (zeige SLC12A2 Antikörper) phosphorylation cascade induced by a low-salt diet and angiotensin II is dependent on WNK3.
WNK3 may serve as a member of a kinase network that facilitates the fine-tuning of renal transepithelial NaCl transport.
WNK3 increases the cytoplasmic localization of Fox-1 (zeige A2BP1 Antikörper), thereby suppressing Fox-1 (zeige A2BP1 Antikörper)-dependent mrna splicing.
suggest that WNK3 is part of the Cl(-)/volume-sensing mechanism necessary for the maintenance of cell volume during osmotic stress and the dynamic modulation of GABA neurotransmission
effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin (zeige AVP Antikörper)
WNK3 is likely a component of one of the mechanisms that determines the balance between renal NaCl reabsorption and K+ secretion.
This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants.
, WNK lysine deficient protein kinase 3
, protein kinase with no lysine 3
, serine/threonine-protein kinase WNK3
, WNK lysine deficient protein kinase 3, pseudogene
, protein kinase lysine-deficient 3