WD Repeat Domain 5 Proteine (WDR5)

WDR5 encodes a member of the WD repeat protein family. Zusätzlich bieten wir Ihnen WDR5 Antikörper (98) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
WDR5 11091 P61964
WDR5 140858 P61965
WDR5 362093 Q498M4
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Top WDR5 Proteine auf antikoerper-online.de

Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 11 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Human His tag   1 mg Anmelden zum Anzeigen 2 bis 3 Tage

WDR5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)
Rat (Rattus) ,

Am meisten referenzierte WDR5 Proteine

  1. Human WDR5 Protein expressed in Wheat germ - ABIN1325241 : Sathi, Tsujigiwa, Ito, Siar, Katase, Tamamura, Harada, Nagatsuka: Osteogenic genes related to the canonic WNT pathway are down-regulated in ameloblastoma. in Oral surgery, oral medicine, oral pathology and oral radiology 2012 (PubMed)

Weitere Proteine zu WD Repeat Domain 5 (WDR5) Interaktionspartnern

Xenopus laevis WD Repeat Domain 5 (WDR5) Interaktionspartner

  1. we found evidence that Setd1b, a maternally provided methyltransferase, is required for organizer gene expression. Our findings indicate that Wdr5-mediated H3K4 trimethylation plays a part in the organizer formation and dorsal axis development that are controlled by the maternal Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.

  2. The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox (zeige MSH2 Proteine) gene expression.

Human WD Repeat Domain 5 (WDR5) Interaktionspartner

  1. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis

  2. WDR5 functions to sustain proper execution of DNA replication in pancreatic ductal adenocarcinoma cells, as previously suggested by replication stress studies involving MLL1, and c-Myc (zeige MYC Proteine), also found to interact with WDR5.

  3. This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 and KAT2A (zeige KAT2A Proteine) complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.

  4. WDR5 shows a direct binding to the ZNF407 promoter.

  5. Taken together, these data suggest that WDR5 is directly involved in p53 (zeige TP53 Proteine) signaling pathway. Our studies provide a new insight into WDR5 functions in A549 cells.

  6. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

  7. WDR5 over-expression is associated with poor breast cancer clinical outcome.

  8. Results identify WDR5 as a key cofactor for N-Myc (zeige MYCN Proteine)-regulated transcriptional activation and tumorigenesis and as a novel therapeutic target for MYCN (zeige MYCN Proteine)-amplified neuroblastomas.

  9. BIG3 may block the KPNAs (KPNA1 (zeige KPNA1 Proteine), KPNA5 (zeige KPNA5 Proteine), and KPNA6 (zeige KPNA6 Proteine)) binding region(s) of PHB2 (zeige PHB2 Proteine).

  10. solution structures of the MLL3 core complex assembled with and without WDR5 by small angle x-ray scattering show similar overall topologies

Mouse (Murine) WD Repeat Domain 5 (WDR5) Interaktionspartner

  1. Cbx8 (zeige CBX8 Proteine) associates with non-PRC1 (zeige PRC1 Proteine) complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch (zeige NOTCH1 Proteine) gene expression.

  2. Wdr5 suppression also reduced IFNgamma, Il-1beta (zeige IL1B Proteine), and TNFalpha (zeige TNF Proteine) induced chemokine (zeige CCL1 Proteine) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis

  3. results suggest that specific RNAs are integral inputs into the WDR5-MLL (zeige MLL Proteine) complex for maintenance of the active chromatin state and embryonic stem cell fates

  4. Data show that broad association of myc proto-oncogene protein MYC (zeige MYC Proteine) with chromatin depends on interaction with the WD40 (zeige DCAF12L2 Proteine)-repeat protein WDR5.

  5. BIG3 inhibits insulin (zeige INS Proteine) granule biogenesis and insulin (zeige INS Proteine) secretion.

  6. BIG3 negatively regulates insulin (zeige INS Proteine) granule exocytosis by restricting insulin (zeige INS Proteine) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.

  7. Depletion of KAT2B (zeige KAT2B Proteine) or WDR5 decreased gluconeogenic gene expression.

  8. analysis of a novel mechanism for epigenetic control of SMC (zeige DYM Proteine)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes

  9. Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (zeige MLLT1 Proteine) (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.

  10. Characterization of a novel WDR5-binding site that recruits RbBP5 (zeige RBBP5 Proteine) through a conserved motif to enhance methylation of histone H3 (zeige HIST3H3 Proteine) lysine 4 by mixed lineage leukemia protein-1.

WDR5 Protein Überblick

Protein Überblick

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

Genbezeichner und Symbole assoziert mit WD Repeat Domain 5 Proteine (WDR5)

  • WD repeat domain 5 (wdr5)
  • WD repeat domain 5 L homeolog (wdr5.L)
  • WD repeat domain 5 S homeolog (wdr5.S)
  • WD repeat domain 5 (WDR5)
  • WD repeat domain 5 (Wdr5)
  • 2410008O07Rik Protein
  • AA408785 Protein
  • AA960360 Protein
  • Big Protein
  • Big-3 Protein
  • MGC80538 Protein
  • MGC81485 Protein
  • SWD3 Protein
  • wdr5-a Protein
  • wdr5-b Protein
  • wu:fk47f04 Protein
  • xwdr5 Protein
  • zgc:56591 Protein
  • zgc:76895 Protein

Bezeichner auf Proteinebene für WD Repeat Domain 5 Proteine (WDR5)

WD repeat domain 5 , WD repeat-containing protein 5 , BMP2-induced 3-kb gene protein , SWD3, Set1c WD40 repeat protein, homolog , WD-repeat protein 5 , WD repeat-containing protein BIG-3

406372 Danio rerio
446809 Xenopus laevis
447447 Xenopus laevis
496891 Xenopus (Silurana) tropicalis
11091 Homo sapiens
140858 Mus musculus
362093 Rattus norvegicus
100125836 Bos taurus
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