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WDR5 encodes a member of the WD repeat protein family. Zusätzlich bieten wir Ihnen WDR5 Antikörper (98) und viele weitere Produktgruppen zu diesem Protein an.
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Human WDR5 Protein expressed in Wheat germ - ABIN1325241
Sathi, Tsujigiwa, Ito, Siar, Katase, Tamamura, Harada, Nagatsuka: Osteogenic genes related to the canonic WNT pathway are down-regulated in ameloblastoma. in Oral surgery, oral medicine, oral pathology and oral radiology 2012
we found evidence that Setd1b, a maternally provided methyltransferase, is required for organizer gene expression. Our findings indicate that Wdr5-mediated H3K4 trimethylation plays a part in the organizer formation and dorsal axis development that are controlled by the maternal Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.
The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox (zeige MSH2 Proteine) gene expression.
WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis
WDR5 functions to sustain proper execution of DNA replication in pancreatic ductal adenocarcinoma cells, as previously suggested by replication stress studies involving MLL1, and c-Myc (zeige MYC Proteine), also found to interact with WDR5.
This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 and KAT2A (zeige KAT2A Proteine) complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.
WDR5 shows a direct binding to the ZNF407 promoter.
Taken together, these data suggest that WDR5 is directly involved in p53 (zeige TP53 Proteine) signaling pathway. Our studies provide a new insight into WDR5 functions in A549 cells.
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
WDR5 over-expression is associated with poor breast cancer clinical outcome.
Results identify WDR5 as a key cofactor for N-Myc (zeige MYCN Proteine)-regulated transcriptional activation and tumorigenesis and as a novel therapeutic target for MYCN (zeige MYCN Proteine)-amplified neuroblastomas.
BIG3 may block the KPNAs (KPNA1 (zeige KPNA1 Proteine), KPNA5 (zeige KPNA5 Proteine), and KPNA6 (zeige KPNA6 Proteine)) binding region(s) of PHB2 (zeige PHB2 Proteine).
solution structures of the MLL3 core complex assembled with and without WDR5 by small angle x-ray scattering show similar overall topologies
Cbx8 (zeige CBX8 Proteine) associates with non-PRC1 (zeige PRC1 Proteine) complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch (zeige NOTCH1 Proteine) gene expression.
Wdr5 suppression also reduced IFNgamma, Il-1beta (zeige IL1B Proteine), and TNFalpha (zeige TNF Proteine) induced chemokine (zeige CCL1 Proteine) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis
results suggest that specific RNAs are integral inputs into the WDR5-MLL (zeige MLL Proteine) complex for maintenance of the active chromatin state and embryonic stem cell fates
Data show that broad association of myc proto-oncogene protein MYC (zeige MYC Proteine) with chromatin depends on interaction with the WD40 (zeige DCAF12L2 Proteine)-repeat protein WDR5.
BIG3 inhibits insulin (zeige INS Proteine) granule biogenesis and insulin (zeige INS Proteine) secretion.
BIG3 negatively regulates insulin (zeige INS Proteine) granule exocytosis by restricting insulin (zeige INS Proteine) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.
Depletion of KAT2B (zeige KAT2B Proteine) or WDR5 decreased gluconeogenic gene expression.
analysis of a novel mechanism for epigenetic control of SMC (zeige DYM Proteine)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes
Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (zeige MLLT1 Proteine) (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
Characterization of a novel WDR5-binding site that recruits RbBP5 (zeige RBBP5 Proteine) through a conserved motif to enhance methylation of histone H3 (zeige HIST3H3 Proteine) lysine 4 by mixed lineage leukemia protein-1.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
WD repeat domain 5
, WD repeat-containing protein 5
, BMP2-induced 3-kb gene protein
, SWD3, Set1c WD40 repeat protein, homolog
, WD-repeat protein 5
, WD repeat-containing protein BIG-3