UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) Proteine (GALNT6)

GALNT6 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Zusätzlich bieten wir Ihnen GALNT6 Antikörper (52) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GALNT6 207839 Q8C7U7
GALNT6 11226 Q8NCL4
Ratte GALNT6 GALNT6 100361647  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$225.40
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
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GALNT6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
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Human , ,
, , ,

Weitere Proteine zu UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) (GALNT6) Interaktionspartnern

Mouse (Murine) UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) (GALNT6) Interaktionspartner

  1. This paper describes the identification and cloning of the orthologous human enzyme of mouse UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6.

Human UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) (GALNT6) Interaktionspartner

  1. GALNT6 knockdown decreased phosphorylation of EGFR (zeige EGFR Proteine), whereas GALNT6 overexpression increased the phosphorylation. Results suggest that GALNT6 expression is associated with poor prognosis of ovarian cancer and enhances the aggressive behavior of ovarian cancer cells by regulating EGFR (zeige EGFR Proteine) activity.

  2. GalNAcT6 role in cancer [review]

  3. Findings show that the expression of GalNAc-T6 in endometrial carcinoma is significantly related to E-cadherin (zeige CDH1 Proteine) expression, and better prognosis and overall survival.

  4. Study showed that GalNAc-T6 expression in epithelial ovarian carcinoma was different according to pathological type. In low-grade serous carcinoma, GalNAc-T6 expression may contribute to improved long-term survival.

  5. GALNT6-induced O-glycosylation is critical for the stability, subcellular localization, and anti-apoptotic function of GRP78 (zeige HSPA5 Proteine) protein in cancer cells. We also suggest that GRP78 (zeige HSPA5 Proteine) might enhance the activity of GALNT6 in carcinogenesis through driving Golgi-to-ER relocation of GALNT6.

  6. knockdown of GALNT6 caused drastic morphological changes of pancreatic cells, accompanied with the cadherin switching from P-cadherin to E-cadherin (zeige CDH1 Proteine).

  7. Role of N-acetylgalactosaminyltransferase (zeige B4GALNT2 Proteine) 6 in early tumorigenesis and formation of metastasis.

  8. These data suggest that excess O-glycosylation on APP (zeige APP Proteine) by GalNAc-T6 inhibits Abeta (zeige APP Proteine) production.

  9. GALNT6-fibronectin (zeige FN1 Proteine) pathway should be a critical component for breast cancer development and progression.

  10. Expression of ppGalNAc-T6 is significantly higher in breast cancer compared to 'normal'/benign breast tissue samples. ST6GalNAc-I (zeige ST6GALNAC1 Proteine) expression in breast cancer is associated with better prognosis.

Xenopus laevis UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) (GALNT6) Interaktionspartner

  1. These enzymes, xGalNAc-T6 and xGalNAc- T16 (zeige FBLN3 Proteine), from different branches of the N-acetylgalactosaminyltransferase (zeige B4GALNT2 Proteine) do not only display differential substrate specificities, but also specific and distinct expression pattern and biological activities in vivo.

GALNT6 Protein Überblick

Protein Überblick

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.

Genbezeichner und Symbole assoziert mit GALNT6

  • polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6)
  • polypeptide N-acetylgalactosaminyltransferase 6 (Galnt6)
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) (galnt6)
  • 4632410F13 Protein
  • AW047994 Protein
  • fc23d02 Protein
  • fc56f12 Protein
  • galnac-t6 Protein
  • galnact6 Protein
  • wu:fc23d02 Protein
  • wu:fc56f12 Protein
  • zgc:77836 Protein

Bezeichner auf Proteinebene für GALNT6

polypeptide N-acetylgalactosaminyltransferase 6 , UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6 , galNAc-T6 , polypeptide GalNAc transferase 6 , pp-GaNTase 6 , protein-UDP acetylgalactosaminyltransferase 6 , N-acetylgalactosaminyltransferase T-6 , Protein-UDP acetylgalactosaminyltransferase 6 , GalNAc transferase 6 , UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6 , UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)

GENE ID SPEZIES
607787 Canis lupus familiaris
429501 Gallus gallus
506903 Bos taurus
207839 Mus musculus
406477 Danio rerio
11226 Homo sapiens
100381149 Xenopus laevis
100361647 Rattus norvegicus
100716943 Cavia porcellus
100348815 Oryctolagus cuniculus
100060897 Equus caballus
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