Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
GALNT6 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Zusätzlich bieten wir Ihnen GALNT6 Antikörper (52) und viele weitere Produktgruppen zu diesem Protein an.
Showing 4 out of 7 products:
This paper describes the identification and cloning of the orthologous human enzyme of mouse UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6.
O-glycosylation of ER-alpha by GALNT6 in breast cancer cells.
these data strongly suggest that aberrant GalNAc-T6 expression and site-specific glycosylation is involved in oncogenic transformation.
GALNT6 knockdown decreased phosphorylation of EGFR, whereas GALNT6 overexpression increased the phosphorylation. Results suggest that GALNT6 expression is associated with poor prognosis of ovarian cancer and enhances the aggressive behavior of ovarian cancer cells by regulating EGFR activity.
GalNAcT6 role in cancer [review]
Findings show that the expression of GalNAc-T6 in endometrial carcinoma is significantly related to E-cadherin expression, and better prognosis and overall survival.
Study showed that GalNAc-T6 expression in epithelial ovarian carcinoma was different according to pathological type. In low-grade serous carcinoma, GalNAc-T6 expression may contribute to improved long-term survival.
GALNT6-induced O-glycosylation is critical for the stability, subcellular localization, and anti-apoptotic function of GRP78 protein in cancer cells. We also suggest that GRP78 might enhance the activity of GALNT6 in carcinogenesis through driving Golgi-to-ER relocation of GALNT6.
knockdown of GALNT6 caused drastic morphological changes of pancreatic cells, accompanied with the cadherin switching from P-cadherin to E-cadherin.
Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis.
These data suggest that excess O-glycosylation on APP by GalNAc-T6 inhibits Abeta production.
GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression.
ppGalNAc-T6 is an IHC marker associated with venous invasion in gastric carcinoma and may contribute to the understanding of the molecular mechanisms that underlie aberrant glycosylation in gastric carcinogenesis and in gastric carcinoma.
Expression of ppGalNAc-T6 is significantly higher in breast cancer compared to 'normal'/benign breast tissue samples. ST6GalNAc-I expression in breast cancer is associated with better prognosis.
These enzymes, xGalNAc-T6 and xGalNAc- T16, from different branches of the N-acetylgalactosaminyltransferase do not only display differential substrate specificities, but also specific and distinct expression pattern and biological activities in vivo.
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.
polypeptide N-acetylgalactosaminyltransferase 6
, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
, polypeptide GalNAc transferase 6
, pp-GaNTase 6
, protein-UDP acetylgalactosaminyltransferase 6
, N-acetylgalactosaminyltransferase T-6
, Protein-UDP acetylgalactosaminyltransferase 6
, GalNAc transferase 6
, UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6
, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)