Transient Receptor Potential Cation Channel, Subfamily V, Member 3 Proteine (TRPV3)

TRPV3 product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. Zusätzlich bieten wir Ihnen Transient Receptor Potential Cation Channel, Subfamily V, Member 3 Antikörper (250) und Transient Receptor Potential Cation Channel, Subfamily V, Member 3 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TRPV3 162514 Q8NET8
TRPV3 246788 Q8K424
Ratte TRPV3 TRPV3 497948  
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Showing 6 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,506.65
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human TRPV3 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$696.46
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TRPV3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3) Interaktionspartnern

Human Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3) Interaktionspartner

  1. Study presents the cryo-electron microscopy structures of apo and sensitized human TRPV3, as well as several structures of TRPV3 in the presence of the common thermoTRPV agonist 2-aminoethoxydiphenyl borate (2-APB). Our results show alpha-to-pi-helix transitions in the S6 during sensitization, and suggest a critical role for the S4-S5 linker pi-helix during ligand-dependent gating.

  2. Study data show that TRPV3 is functionally expressed on human epidermal keratinocytes and that it plays a role in cutaneous inflammatory processes.

  3. Data suggest that Thr264 in TRPV3 is key ERK1 phosphorylation site mediating EGFR-induced sensitization of TRPV3 to stimulate signaling pathways involved in regulating skin homeostasis. (TRPV3 = transient receptor potential cation channel subfamily V member-3; ERK1 = extracellular signal-regulated kinase-1; EGFR = epidermal growth factor receptor)

  4. This study identified a direct regulatory effect of MBTPS2 on TRPV3 which can partially contribute to the overlapping clinical features of IFAP and Olmsted syndromes under a common signaling pathway.

  5. TRPV3 may contribute to pruritus in burn scars through TSLP.

  6. the expression of transient receptor potential vanilloid-1 (TRPV1), transient receptor potential vanilloid-2 (TRPV2) and transient receptor potential vanilloid-3 (TRPV3) channels in native human odontoblasts, was examined.

  7. TRPV3 was highly expressed in the infiltrating eosinophils and mucosal epithelium of the nasal polyps of ECRS, and further that the more severe the refractoriness was after surgery, the higher the TRPV3 expression was in nasal polyps.

  8. Data indicate that the restoration of a single residue that is apparently missing in the use-dependent homologs could largely eliminate the use dependence of heat sensitivity of vanilloid receptor transient receptor potential 3 (TRPV3).

  9. TRPV3 mutants causing Olmsted Syndrome induce impaired cell adhesion and nonfunctional lysosomes

  10. *We describe two cases of Olmsted-like syndrome in a Mongolian family. *The underlying cause was a previously undescribed G573V point mutation in TRPV3.

  11. The results of the present study show that polymorphism of TRPV3 contributed towards symptom severity in FM.

  12. A novel mutation in TRPV3 gene causes atypical familial Olmsted syndrome in a Chinese family.

  13. High Transient receptor potential vanilloid 3 protein expression could promote the proliferation of lung cancer cells. Transient receptor potential vanilloid 3 inhibition decreased [Ca2+]i of lung cancer cells and cell cycle arrest at the G1/S boundary.

  14. these data suggest that TRPV3 sparklets cause dilation of cerebral parenchymal arterioles by activating IK and SK channels in the endothelium

  15. TRPV3 missense mutation identified as a cause of the rare Olmsted syndrome.

  16. Hypoxia, FIH inhibitors and mutation of asparagine 242 all potentiated TRPV3-mediated current, without altering TRPV3 protein levels, indicating that oxygen-dependent hydroxylation inhibits TRPV3 activity.

  17. Using multiple sequence alignments as source for evolutionary, bioinformatics and statistical analysis, we have analyzed the evolutionary profiles for TRPV1, TRPV2, TRPV3 and TRPV4

  18. TPRV3 was significantly elevated in the epidermis of burn scars with pruritus.

  19. Study illustrates the antiadipogenic role of TRPV3 in the adipocytes.

  20. this study provides powerful tools to broaden our understanding of ligand interaction with TRPV channels, and the availability of purified human TRPV3 opens up perspectives for further structural and functional studies

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3) Interaktionspartner

  1. Inhibition of TRPV3 by osthole or silencing by knockout of the TRPV3 gene significantly reduced the scratching.

  2. role of TRPV3 as a strong modulator of cutaneous vascular thermoregulatory mechanisms.

  3. results demonstrate that carvacrol from plant oregano is a skin sensitizer or allergen; TRPV3 is involved in the initial phase and the sustained phase of pruritus, whereas TRPA1 likely contributes to the initial phase.

  4. These results suggest that TRPV4, TRPV3 and TRPM8 proteins, but not their ion channel activities are necessary for the induction of CIPs at 32 degrees C. Identification of proteins that differentially interact with these TRP channels at 37 degrees C and 32 degrees C would help elucidate the underlying mechanisms of CIP induction by hypothermia.

  5. TRPV3 is involved in the development of ear edema caused by arachinonic acid.

  6. It was concluded that TRPV3 is expressed in a discrete subpopulation of vagal afferent neurons and may contribute to vagal afferent signaling either directly or in combination with TRPV1.

  7. findings suggest that although TRPV3 agonism induces hypothermia in rodents, it may have a limited potential as a novel pharmacological method for induction of hypothermia

  8. TRPV3 activation led to a decrease in embryonic stem cell proliferation. Cell cycle analysis revealed that TRPV3 activation increased the percentage of cells in G2/M phase.

  9. In vivo evidence of a cooperative role between skin-derived TRPV3 and primary sensory neurons-enriched TRPV1 in modulation of moderate and noxious heat temperature sensation.

  10. We found that NA indeed potentiated TRPV3 while inhibited TRPV2 and TRPV4

  11. Study illustrates the antiadipogenic role of TRPV3 in the adipocytes.

  12. Investigated the role of TRPV3 to wound healing using a tooth extraction model and found that oral wound closure was delayed in TRPV3KO compared with that in WT. TRPV3 mRNA was up-regulated in wounded tissues, so TRPV3 may contribute to oral wound repair.

  13. Demonstrate similarities but also notable differences in TRPV3 pharmacology between recombinant and native systems.

  14. a gain-of-function mutation in TRPV3 (TRPV3Gly573Ser) shows that increasing skin temperature is associated with the modulation of dermal dendritic cells

  15. TRPV3-ARD with characteristic finger 3 loop likely plays an important role in channel function and pharmacology.

  16. This study demonistrated that Loss of interneuron long-term depression and attenuated pyramidal cell long-term potentiation in Trpv3 knockout mice

  17. temperature-dependent conformations of single amino acids in TRP channels

  18. Responses to camphor were totally lost in mTRPV3-C619S mutant.

  19. The findings suggest that epidermal TRPV3 is tonically inhibited by both extracellular and intracellular Mg(2+), which act on both sides of the channel pore loop.

  20. TRPV3 is a therapeutic target for itch

Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3) Protein Überblick

Protein Überblick

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit TRPV3

  • transient receptor potential cation channel subfamily V member 3 (TRPV3)
  • transient receptor potential cation channel, subfamily V, member 3 (Trpv3)
  • 1110036I10Rik Protein
  • AI644701 Protein
  • Nh Protein
  • OLMS Protein
  • VRL3 Protein

Bezeichner auf Proteinebene für TRPV3

transient receptor potential cation channel, subfamily V, member 3 , transient receptor potential cation channel subfamily V member 3-like , VRL-3 , transient receptor potential cation channel subfamily V member 3 , vanilloid receptor-like 3 , vanilloid receptor-related osmotically activated channel protein , TRP ion channel TRPV3 , non-hair , heat sensitive channel TRPV3

GENE ID SPEZIES
771945 Gallus gallus
100483890 Ailuropoda melanoleuca
162514 Homo sapiens
246788 Mus musculus
497948 Rattus norvegicus
491218 Canis lupus familiaris
100515051 Sus scrofa
523538 Bos taurus
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