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The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. Zusätzlich bieten wir Ihnen TCF12 Antikörper (93) und viele weitere Produktgruppen zu diesem Protein an.
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HDAC1 (zeige HDAC1 Proteine) promoted migration and invasion of gallbladder tumor cells by binding with TCF12 to promote epithelial mesenchymal transformation.
Study describes the identification of three large inherited intragenic exon deletions in TCF12 using whole-genome sequencing and one large inherited duplication using targeted TCF12 sequencing in patients with craniosynostosis.
Heb expression is regulated by Med19 (zeige MED19 Proteine) in breast cancer cells.
enforced expression of transcription factor 12 suppressed cell proliferation, migration, and invasion in vitro and inhibited tumor growth in vivo. In conclusion, transcription factor 12 protein may be a novel molecule which plays a critical role in prostate cancer progression and patients' prognosis, suggesting it might be a promising therapeutic target for prostate cancer therapy
HEB may be involved in GBM cell proliferation, as HEB silencing reduced proliferation in cells cultured as monolayers or neurospheres. Furthermore, the results suggested a potential role for HEB in the maintenance of GBM stem cells, as HEB silencing affected the differentiation capacity of cells.
Two novel translocations leading to the inactivation of RUNX1 (zeige RUNX1 Proteine) and its partners SIN3A (zeige SIN3A Proteine) and TCF12 in myeloid leukemia (zeige BCL11A Proteine).
Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing.
show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type
several familial cases of coronal synostosis associated with mutations in TCF12
In t(8;21) leukemia cells, the two E proteins, HEB and E2A (zeige TCF3 Proteine), function as components of the stable AML1 (zeige RUNX1 Proteine)-ETO (zeige RUNX1T1 Proteine)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
Tcf12 is a transcription factor highly expressed in the nuclei of stem cells and its downregulation plays an essential role in osteoblast differentiation.
we identified transcription factor TCF12 as a new target of miR (zeige MLXIP Proteine)-211 in oral squamous cell carcinoma
HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells
severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 (zeige TWIST1 Proteine) genes highlights the key role of TCF12 acting with TWIST1 (zeige TWIST1 Proteine) in the normal development of the coronal sutures
Deficiency in the E proteins, E2A (zeige TCF3 Proteine) and HEB, led to increased frequency of terminally differentiated effector KLRG1 (zeige KLRG1 Proteine)(hi) CD8 (zeige CD8A Proteine)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Deletion of HEB and E2A (zeige TCF3 Proteine) in DP thymocytes specifically blocked the development of CD4 (zeige CD4 Proteine)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (zeige ID3 Proteine) allowed CD4 (zeige CD4 Proteine)(+) T cell development but blocked CD8 (zeige CD8A Proteine)(+) lineage development.
the earliest event in B-cell specification involves the induction of FOXO1 (zeige FOXO1 Proteine) expression and requires the combined activities of E2A (zeige TCF3 Proteine) and HEB
These results showed a new set of interactions between HEB, Notch1 (zeige NOTCH1 Proteine), and GATA3 (zeige GATA3 Proteine) that regulate the T-cell fate choice in developing thymocytes.
Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.
HEB is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
transcription factor 12
, transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)
, DNA-binding protein HTF4
, E-box-binding protein
, class B basic helix-loop-helix protein 20
, helix-loop-helix transcription factor 4
, transcription factor HTF-4
, class A helix-loop-helix transcription factor ME1
, SCBP alpha
, salivary-specific cAMP response element-binding protein alpha
, basic helix-loop-helix protein
, class A helix-loop-helix transcription factor GE1