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This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. Zusätzlich bieten wir Ihnen TSSK6 Antikörper (65) und viele weitere Produktgruppen zu diesem Protein an.
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Human TSSK6 Protein expressed in Wheat germ - ABIN1323987
Li, Sosnik, Brassard, Reese, Spiridonov, Bates, Johnson, Anguita, Visconti, Salicioni: Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. in Molecular human reproduction 2010
findings, for the first time, suggested an association of c.822+126T>G/C in TSSK6 with spermatogenic impairment in humans in which allele T may be a risk factor for male infertility, while alleles C and G may decrease susceptibility to male infertility
results demonstrate that SSTK is required for proper postmeiotic chromatin remodeling and male fertility
TSSK6 is required for gammaH2AX formation during spermiogenesis, and also link gammaH2AX to the histone-to-protamine transition and male fertility.
HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation
HSP90 is essential for functional maturation of the kinase and identify SIP as a cochaperone that is critical to the HSP90-mediated activation of SSTK.
This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm.
testis-specific serine kinase 6
, cancer/testis antigen 72
, serine/threonine protein kinase SSTK
, small serine/threonine kinase
, testis-specific serine/threonine-protein kinase 6
, serine/threonine-protein kinase SSTK
, testis-specific kinase 6