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Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Zusätzlich bieten wir Ihnen TSPYL5 Antikörper (40) und viele weitere Produktgruppen zu diesem Protein an.
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The expression of spermatogenic phenotypes of TSPY1 defects is independent of variations in TSPYL1 and TSPYL5 in the Han Chinese population.
Transcriptome analysis of MUC16 (zeige MUC16 Proteine) KD showed a downregulation (P = 0.005) of TSPYL5 gene, which encodes for a testis-specific (zeige THEG Proteine) Y-like protein...Also, MUC16 (zeige MUC16 Proteine) overexpression induced cisplatin and gemcitabine resistance by downregulation of p53 (zeige TP53 Proteine)
More advanced tumor tissues had an inverse correlation between methylation and TSPYL5 gene or protein expression. TSPYL5 may play a role in sensitivity to chemotherapy likely by modulating pleiotropic protein such as CDKN1A.
Increasing the expression of TSPYL5 in HT29 cells or inhibiting miR (zeige MLXIP Proteine)-19-5p promotes apoptosis of HT29 cells.
Overexpression of miR (zeige MLXIP Proteine)-629 promoted the cell ability of migration and invasion and reduced ovarian cancer cell apoptosis. In addition, elevated cancer inhibition ability of TSPYL5 induced by the miR (zeige MLXIP Proteine)-629 inhibitor was significantly blocked by inhibition of TSPYL5.
TSPYL5 overexpression is associated with Down syndrome.
Suggest that hypermethylation of ACP1 (zeige ACP1 Proteine), BMP4 (zeige BMP4 Proteine), and TSPYL5 are common events in HCC (zeige FAM126A Proteine) and could be used as potentially detectable biomarkers in HCC (zeige FAM126A Proteine) tissues.
TSPYL5 knockdown decreased, and overexpression increased aromatase (CYP19A1 (zeige CYP19A1 Proteine)) expression through the skin/adipose (I.4) promoter.
Data identify TSPYL5 as a suppressor of p53 (zeige TP53 Proteine) function through its interaction with USP7 (zeige USP7 Proteine).
This study provides the first demonstration that TSPYL5 modulates cell growth and sensitization of cells to the detrimental effects of damaging agents via regulation of p21(WAF1/Cip1 (zeige CDKN1A Proteine)) and PTEN/AKT (zeige AKT1 Proteine) pathway.
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination\; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7 (By similarity).
TSPY-like protein 5
, testis-specific Y-encoded-like protein 5