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C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1\; MIM 613128) and CTC1 (C17ORF68\; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009].. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Studies indicate telomere-binding proteins CTC1-STN1-TEN1 (CST) dysfunction and mutation is associated with several genetic diseases and cancers [Review].
CTC1-STN1 terminates TERT while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.
CTC1/STN1/TEN1 (CST) deficiency diminishes HU-induced RAD51 foci formation.
The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells.
TERT-mediated G-strand extension and Ctc1-Stn1-Ten1-mediated C-strand fill-in are equally important for telomere length maintenance.
reveal a critical role for human Stn1 in telomere length maintenance and function, supporting the model that efficient replication of telomeric repeats is critical for long-term viability of normal somatic mammalian cells
The mammalian CST (CTC1-STN1-TEN1) complex is directly involved at several stages of telomere end formation and CST seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to complete telomere replication.
data indicate that hTen1 is critical for the telomeric function of hCST, both in telomere protection and downregulation of telomerase function
TEN1 likely functions in conjunction with CTC1 and STN1 at the telomere and elsewhere in the genome.
the human CST (CTC1, STN1 and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1)-TPP1 telomerase processivity factor
Ctc1-Stn1-Ten1 is a replication protein A (RPA)-like complex that is not directly involved in conventional DNA replication at forks but plays a role in DNA metabolism frequently required by telomeres.
C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1\; MIM 613128) and CTC1 (C17ORF68\; MIM 613129) (Miyake et al., 2009
CST complex subunit TEN1
, TEN1 telomerase capping complex subunit homolog
, protein telomeric pathways with STN1 homolog
, telomere length regulation protein TEN1 homolog
, telomeric pathways in association with Stn1, number 1