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S1PR4 is a member of the endothelial differentiation, G-protein-coupled EDG receptor gene family.
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High S1PR4 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis.
S1PR4 missense mutation is associated with variant blood cell traits.
Shear stress did not induce rapid dephosphorylation of beta-arrestin-1 or rapid internalization of S1P3, indicating no GPCR activation. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs.
Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7 (zeige TLR7 Proteine)/9 ligands to allow high IFN-alpha (zeige IFNA Proteine) production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha (zeige IFNA Proteine) secretion.
S1P2 (zeige S1PR2 Proteine) translocation to the nucleus is regulated by an autocrine loop involving S1P (zeige MBTPS1 Proteine) and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src (zeige SRC Proteine) to the nucleus appears to be regulated by a mechanism that does not involve S1P3 (zeige S1PR3 Proteine) or S1P4.
analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P (zeige MBTPS1 Proteine)-R) agonists
findings highlight an important role for S1P (zeige MBTPS1 Proteine)(4) and SK1 in ER(-) breast cancer progression.
Data show that S1P4 uses HER2 (zeige ERBB2 Proteine) to regulate extracellular signal regulated kinase-1/2 (zeige MAPK3 Proteine) MDA-MB-453 breast cancer cells.
Data report that sphingosine 1-ph (zeige MBTPS1 Proteine)osphate receptor 4 (S1P(4)) is specifically up-regulated during the development of human megakaryocytes from progenitor cells
Mutation of the ligand selectivity residue from glutamic acid to glutamine confers lysophosphatidic acid sensitivity with preference for short-chain species
Data shows a reduced abundance of pDC (zeige PDC Proteine), particularly CD4 (zeige CD4 Proteine)- pDC (zeige PDC Proteine), in all organs of S1PR4-deficient vs. wildtype mice.
analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P (zeige S1PR1 Proteine)-R) agonists
S1P4 signaling is involved in the regulation of dendritic cell function and TH17 T-cell differentiation. S1P4-mediated S1P (zeige S1PR1 Proteine) signaling also modifies the course of various immune diseases in a murine model
Megakaryocytes generated from S1P (zeige S1PR1 Proteine)(4)-deficient murine bone marrow showed atypical and reduced formation of proplatelets in vitro.
s1p(4) maps to mouse chromosome 10 and has similar tissue distribution to mouse Gna15; transcription of the two genes may be under control of the same enhancer elements
binding pocket of mS1P4 (mouse S1P4) has recognition sites for the anionic phosphate and cationic ammonium groups that are equidistant from the end of the non-polar tail
S1P4 mediates immunosuppressive effects of S1P (zeige S1PR1 Proteine) by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10 (zeige IL10 Proteine)
This gene is a member of the endothelial differentiation, G-protein-coupled EDG receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.
endothelial differentiation, G protein coupled receptor 6
, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
, sphingosine 1-phosphate receptor 4
, sphingosine-1-phosphate receptor 4
, S1P receptor 4
, S1P receptor Edg-6
, endothelial differentiation G-protein coupled receptor 6
, endothelial differentiation, G-protein-coupled receptor 6
, sphingosine 1-phosphate receptor Edg-6
, S1p receptor 4
, endothelial differentiation G-protein-coupled receptor 6
, lysophospholipid receptor C1
, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6