anti-Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) Antikörper

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Zusätzlich bieten wir Ihnen SPAM1 Proteine (9) und SPAM1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SPAM1 20690 P48794
SPAM1 6677 P38567
SPAM1 117037 Q62803
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Top anti-SPAM1 Antikörper auf antikoerper-online.de

Showing 10 out of 33 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Host: Rabbit Target Name: SPAM1 Sample Type: 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: SPAM1 Sample Type: Human Adult Placenta Antibody Dilution: 1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
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Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$305.71
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Human Kaninchen Unkonjugiert WB SPAM1 Antibody (C-term)  western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the SPAM1 antibody detected the SPAM1 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB Western blot analysis of extracts of PC-3, using SPAM antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277103 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
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Human Kaninchen Unkonjugiert IF, IHC, WB Western blot analysis of extracts of various cell lines, using SPAM1 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$366.77
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Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: SPAM1 Antibody [NBP1-81637] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY401088) Immunohistochemistry-Paraffin: SPAM1 Antibody [NBP1-81637] - Immunohistochemical staining of human testis shows distinct positivity in spermatids. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
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Human Kaninchen Unkonjugiert IF/ICC, WB Western blot analysis of extracts of various cell lines, using SPAM1 antibody (ABIN5971147) at 1/1000 dilution. Immunofluorescence analysis of HeLa cells using SPAM1 antibody (ABIN5971147). Blue: DAPI for nuclear staining. 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
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Human Kaninchen Unkonjugiert WB   50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$551.83
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Human Kaninchen Unkonjugiert IF, WB Western blot analysis of extracts of various cell lines, using SPAM1 antibody. Immunofluorescence analysis of HeLa cells using SPAM1 antibody. 200 μL Anmelden zum Anzeigen 12 bis 14 Tage
$438.90
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Maus Kaninchen Unkonjugiert IHC, WB Immunofluorescence analysis of HeLa cell using SPAM1 antibody. Blue: DAPI for nuclear staining. Western blot analysis of extracts of various cell lines, using SPAM1 antibody. 100 μL Anmelden zum Anzeigen 13 bis 14 Tage
$444.37
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Am meisten referenzierte anti-SPAM1 Antikörper

  1. Human Polyclonal SPAM1 Primary Antibody für ELISA, WB - ABIN562973 : Monzón, Manzanares, Schmid, Casalino-Matsuda, Forteza: Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells. in American journal of respiratory cell and molecular biology 2008 (PubMed)
    Show all 6 Pubmed References

Weitere Antikörper gegen SPAM1 Interaktionspartner

Mouse (Murine) Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) Interaktionspartner

  1. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.

  2. ACR or PRSS21 or both may function cooperatively with SPAM1 in sperm/cumulus penetration

  3. The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase SPAM1 may not be required for fertilization, at least in the mouse.

  4. Entrapment of spontaneous Spam1 mutations, owing to recombination suppression near the Robertsonion translocation junctions, is proposed as the major underlying defect of the sperm dysfunction.

  5. sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg

  6. Epididymal Spam1 is secreted predominantly as insoluble particles. Majority of epididymal Spam1 is released with its lipid anchor, a form in which it can bind to sperm.

  7. Spam1 is a multifunctional protein and that it is less restricted in its expression than previously reported

  8. Sperm adhesion molecule 1 (SPAM1) is distributed in the nonciliated epithelial cells. Efferent ducts have the most intense staining. Spam1 was also present in the accessory organs, the prostate, and seminal vesicles and its fluid.

  9. Testicular compartmentalization of Spam1 RNA provides strong support for the lack of sharing hypothesis, and represents a possible mechanism of Spam1-associated transmission ratio distortion .

  10. Mouse SPAM1 and HYAL5 but not HYALP1 proteins exhibit hyaluronidase activity at neutral pH.

  11. SPAM1 is implicated in fluid reabsorption and urine concentration

  12. First documentation of vesicular interaction with the sperm plasma membrane provides a model for the possible transfer mechanism of SPAM1 and other glycosyl phosphatidylinositol (GPI)-linked proteins to the sperm surface in reproductive fluids.

  13. SPAM1 may function in sperm entry into the cumulus and sperm penetration through the cumulus matrix.

Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) Interaktionspartner

  1. Human posterior head 20 (hPH20) and homo sapiens sperm acrosome associated 1 (hSPACA1) immunocontraceptive epitopes reduced fertility in male/female mice.

  2. results indicate that neither rHuPH20 nor its directly generated HA catabolites have inflammatory properties in the air pouch model, and rHuPH20 can instead inhibit some aspects of inflammation, such as neutrophil infiltration into the air pouch.

  3. HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A and SPAM1.

  4. The interaction between SPAM1, ARSA and HSPA2 in a multimeric complex mediating sperm-egg interaction.

  5. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination.

  6. SPAM1 mRNA & protein occur in all 3 regions of epididymis & vas deferens. It has hyaluronidase activity at pH 7.0. The proximal promoter has epididymal transcription factor sites including androgen receptor elements. Its role may be in sperm maturation.

Cow (Bovine) Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) Interaktionspartner

  1. Bovine testicular hyaluronidase 3D-model demonstrated lysine residue stratification during enzyme modification.

  2. the effect of metal cations on the transglycosylation by bovine testicular hyaluronidase using as substrates metal salts of glycosaminoglycan chains was investigated.

  3. results clearly demonstrate that ejaculated bull sperm possess two forms of sperm adhesion molecule 1(SPAM1): one (epididymal) expressed at the surface, and one (testicular) that interacts with the zona pellucida after the acrosome exocytosis.

  4. The hydrolysis Vm values strongly suggest that as the chain length decreases the hyaluronidase increasingly catalyses transglycosylation rather than hydrolysis.

  5. The simplicity, sensitivity, and versatility of the fluorescent substrate (termed FRET-HA) suggest that it will have utility in a variety of assay platforms and should be a new tool for assessing hyaluronidase activity.

SPAM1 Antigen-Profil

Protein Überblick

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SPAM1

  • sperm adhesion molecule 1 (Spam1) Antikörper
  • sperm adhesion molecule 1 (SPAM1) Antikörper
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog (spam1.L) Antikörper
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1) Antikörper
  • sperm adhesion molecule 1 (spam1) Antikörper
  • AV039194 Antikörper
  • HYA1 Antikörper
  • HYAL1 Antikörper
  • HYAL3 Antikörper
  • HYAL5 Antikörper
  • im:6902904 Antikörper
  • PH-20 Antikörper
  • PH20 Antikörper
  • SPAG15 Antikörper
  • Spam Antikörper
  • spam1 Antikörper
  • XEH1 Antikörper
  • zgc:158668 Antikörper

Bezeichner auf Proteinebene für SPAM1

hyal-PH20 , hyaluronidase PH-20 , hyaluronoglucosaminidase PH-20 , sperm surface protein PH-20 , sperm protein PH-20 , PH-20 protein , sperm surface antigen 2B1 , hyaluronidase , sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog , hyaluronidase, zona pellucida binding , sperm adhesion molecule 1

GENE ID SPEZIES
20690 Mus musculus
100135624 Cavia porcellus
6677 Homo sapiens
100009391 Oryctolagus cuniculus
117037 Rattus norvegicus
398285 Xenopus laevis
353352 Bos taurus
791203 Danio rerio
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