Solute Carrier Organic Anion Transporter Family, Member 1C1 Proteine (SLCO1C1)

SLCO1C1 encodes a member of the organic anion transporter family. Zusätzlich bieten wir Ihnen SLCO1C1 Antikörper (19) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLCO1C1 53919 Q9NYB5
SLCO1C1 58807 Q9ERB5
Ratte SLCO1C1 SLCO1C1 84511 Q9EPZ7
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details

SLCO1C1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human
,
Mouse (Murine)
,

Weitere Proteine zu Solute Carrier Organic Anion Transporter Family, Member 1C1 (SLCO1C1) Interaktionspartnern

Human Solute Carrier Organic Anion Transporter Family, Member 1C1 (SLCO1C1) Interaktionspartner

  1. The genetic variant, rs3794271, located within the PDE3A (zeige PDE3A Proteine)-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures correlated with anti-TNF (zeige TNF Proteine) response in a large UK rheumatoid arthritis cohort.

  2. We found a highly significant association between PDE3A (zeige PDE3A Proteine)-SLCO1C1 and the clinical response to TNF (zeige TNF Proteine) blockers

  3. The PDE3A (zeige PDE3A Proteine)-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF (zeige TNF Proteine) treatment response.

  4. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 (zeige SLCO3A1 Proteine) variant 2, OATP4A1, LAT2 (zeige LAT2 Proteine) and CD98 (zeige SLC3A2 Proteine) were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8 (zeige MCT8 Proteine), MCT10, OATP3A1 (zeige SLCO3A1 Proteine) variant 1 and LAT1 (zeige LAT Proteine) were similar.

  5. The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis.

  6. We have isolated and functionally characterized OATP-F. OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis.

  7. OATP1C1 polymorphisms are associated with fatigue and depression, but do not explain differences in neurocognitive functioning or appreciation of LT4-LT3 combination therapy.

  8. OATP1C1 mediates transport of thyroid hormones and increases the access of these substrates to the intracellular active sites of the deiodinases with no effect of genetic variation

  9. OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels.

Mouse (Murine) Solute Carrier Organic Anion Transporter Family, Member 1C1 (SLCO1C1) Interaktionspartner

  1. This study identified the thyroid hormone (zeige PTH Proteine) transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex

  2. The data demonstrate that OATP1c1 and MCT8 (zeige MCT8 Proteine) expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.

  3. Transporters MCT8 (zeige MCT8 Proteine) and OATP1C1 maintain murine brain thyroid hormone (zeige PTH Proteine) homeostasis.

  4. SLCO1C1 is expressed in the neuronal cell lineage during brain development. Expression of SLCO1C1 may underlie the extraordinary sensitivity of specific neuronal populations to hypothyroxinaemia.

  5. expression of candidate thyroid hormone (zeige PTH Proteine) transporters Lat1 (zeige SLC7A5 Proteine), Mct8 (zeige MCT8 Proteine), Mct10, and Oatp1c1 in mouse cochlear development

  6. OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels.

SLCO1C1 Protein Überblick

Protein Überblick

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit SLCO1C1

  • solute carrier organic anion transporter family member 1C1 (SLCO1C1)
  • solute carrier organic anion transporter family, member 1c1 (Slco1c1)
  • Bsat1 Protein
  • OATP-14 Protein
  • OATP-F Protein
  • OATP1 Protein
  • OATP1C1 Protein
  • Oatp2 Protein
  • Oatp14 Protein
  • Oatpf Protein
  • OATPRP5 Protein
  • Slc21a14 Protein

Bezeichner auf Proteinebene für SLCO1C1

OAT-RP-5 , OATP-14 , organic anion transporter F , organic anion transporter polypeptide-related protein 5 , organic anion transporting polypeptide 14 , organic anion-transporting polypeptide 14 , solute carrier family 21 (organic anion transporter), member 14 , solute carrier family 21 member 14 , solute carrier organic anion transporter family member 1C1 , thyroxine transporter , organic anion transporter 2 , BBB-specific anion transporter type 1 , blood-brain barrier specific anion transporter , blood-brain barrier-specific anion transporter 1

GENE ID SPEZIES
53919 Homo sapiens
609603 Canis lupus familiaris
518047 Bos taurus
100144344 Oryctolagus cuniculus
58807 Mus musculus
84511 Rattus norvegicus
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