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SLC6A2 encodes a member of the sodium symporter family. Zusätzlich bieten wir Ihnen SLC6A2 Antikörper (39) und SLC6A2 Kits (25) und viele weitere Produktgruppen zu diesem Protein an.
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T allele of the SNP rs7194256 in the 3'UTR of the NET gene is more prevalent in diseases where NET impairment is evident, including essential hypertension, depression, panic disorder and postural orthostatic tachycardia syndrome; mechanism involved may include the creation of a binding site for the miRNA miR (zeige MLXIP Proteine)-19-3p, which is, at least in part, regulated by circulating norepinephrine concentrations
Polymorphisms of COMT (zeige COMT Proteine) (c.649G>A), MAO-A (zeige MAOA Proteine) (c.1460C>T), NET (c.1287G>A) Genes and the Level of Catecholamines, Serotonin in Patients with Parkinson's Disease
NET undergoes extensive constitutive internalization and internalized NET mainly is sorted to Rab11-positive recycling endosomes.
In Major Depressive Disorder patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.
This corticotropin releasing factor (zeige CRH Proteine)-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety
a NET 182C and 5-HTTLPR (zeige SLC6A4 Proteine) polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients
NET gene variants are not involved in the etiology of recurrent major depressive disorder in Chinese Han population.
A Cox (zeige COX8A Proteine) regression analysis for remission incidence during the 8-week treatment course significantly depends on SLC6A2 variants (rs28386840, rs40434, and rs187714)from major depression after venlafaxine treatment.
The response to venlafaxine was assessed after 4 weeks of treatment and correlated to serum concentration and functional variants in genes encoding SLC6A2 and SLC6A4 (zeige SLC6A4 Proteine)
polymorphisms of 1287G/A, -182T/C and -3081A/T in the norepinephrine transporter gene are not risk factors in alcohol dependence.
Findings suggest that a combination of forward and reverse EphB1 (zeige EPHB1 Proteine)/2 receptor-mediated signaling contribute to posterior branch of the anterior commissure and corpus callosum axon guidance
During re-epithelialization ephrin-B1 (zeige EFNB1 Proteine) and its receptor EphB2 (zeige EPHB2 Proteine) are both upregulated in vivo, just for the duration of repair.
Differences in gene expression in the mouse frontal cortex with life-long norepinephrine transporter knock-out were studied using a whole-genome microarray approach
In a genetic medulloblastoma model, EphB1 (zeige EPHB1 Proteine) knockout resulted in a significant delay in tumor recurrence following irradiation compared to EphB1 (zeige EPHB1 Proteine)-expressing control tumors.
inhibition of p38 MAPK (zeige MAPK14 Proteine) or the manipulation of NET-Thr (zeige TRH Proteine)(30) motif/phosphorylation via a TAT (zeige TAT Proteine) peptide strategy prevents cocaine-induced NET up-regulation, locomotor sensitization, and conditioned place preference
this is the first report which suggests the beneficial effect of modulation of TRPV1 (zeige TRPV1 Proteine) receptors and NET in Chronic cerebral hypoperfusion vascular dementia
EphB1 (zeige EPHB1 Proteine) expression is activated in the spinal cord in a bone cancer model.
The studies introduce EphB1 (zeige EPHB1 Proteine) as a new venous-restricted marker in a tissue-specific and time-dependent manner.
Reelin (zeige RELN Proteine) induces EphB activation.
role of EphB1 (zeige EPHB1 Proteine) receptors signalling in models of inflammatory and neuropathic pain
This gene encodes a member of the sodium symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
, norepinephrine transporter
, sodium-dependent noradrenaline transporter
, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
, solute carrier family 6 member 5
, NE transporter
, solute carrier family 6 member 2
, NaCl-dependent norepinephrine transporter
, neurotransmitter transporter, noradrenal
, transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
, norepinephrine plasma membrane transporter
, pulmonary norepinephrine plasma membrane transporter
, sodium-dependent noradrenaline transporter-like
, sodium- and chloride-dependent glycine transporter 2-like
, solute carrier family 6 (neurotransmitter transporter, glycine), member 5
, ephrin type-B receptor 1