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SLC6A2 encodes a member of the sodium symporter family. Zusätzlich bieten wir Ihnen SLC6A2 Antikörper (39) und SLC6A2 Kits (25) und viele weitere Produktgruppen zu diesem Protein an.
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Our study indicates that DNA methylation (zeige HELLS Proteine) levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension.
case-control study by genotyping 7 SNPs of SLC6A2, SLC6A3 (zeige SLC6A3 Proteine) and DRD2 (zeige DRD2 Proteine) in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls
T allele of the SNP rs7194256 in the 3'UTR of the NET gene is more prevalent in diseases where NET impairment is evident, including essential hypertension, depression, panic disorder and postural orthostatic tachycardia syndrome; mechanism involved may include the creation of a binding site for the miRNA miR (zeige MLXIP Proteine)-19-3p, which is, at least in part, regulated by circulating norepinephrine concentrations
Polymorphisms of COMT (zeige COMT Proteine) (c.649G>A), MAO-A (zeige MAOA Proteine) (c.1460C>T), NET (c.1287G>A) Genes and the Level of Catecholamines, Serotonin in Patients with Parkinson's Disease
NET undergoes extensive constitutive internalization and internalized NET mainly is sorted to Rab11-positive recycling endosomes.
In Major Depressive Disorder patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.
This corticotropin releasing factor (zeige CRH Proteine)-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety
a NET 182C and 5-HTTLPR (zeige SLC6A4 Proteine) polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients
NET gene variants are not involved in the etiology of recurrent major depressive disorder in Chinese Han population.
A Cox (zeige COX8A Proteine) regression analysis for remission incidence during the 8-week treatment course significantly depends on SLC6A2 variants (rs28386840, rs40434, and rs187714)from major depression after venlafaxine treatment.
Differences in gene expression in the mouse frontal cortex with life-long norepinephrine transporter knock-out were studied using a whole-genome microarray approach
inhibition of p38 MAPK (zeige MAPK14 Proteine) or the manipulation of NET-Thr (zeige TRH Proteine)(30) motif/phosphorylation via a TAT (zeige TAT Proteine) peptide strategy prevents cocaine-induced NET up-regulation, locomotor sensitization, and conditioned place preference
this is the first report which suggests the beneficial effect of modulation of TRPV1 (zeige TRPV1 Proteine) receptors and NET in Chronic cerebral hypoperfusion vascular dementia
Norepinephrine transporter has a greater role in determining baseline analgesia and other analgesic effects in mice than serotonin transporter (zeige SLC6A4 Proteine).
NET expression is essential for development and/or survival of some (5-HT (zeige DDC Proteine)- and calretinin (zeige CALB2 Proteine)-expressing), but not all (nNOS (zeige NOS1 Proteine)-expressing), of these neurons.
propose that amplified norepinephrine transporter function in rictor KO mice enhances accumulation of both norepinephrine and dopamine within the noradrenergic neuron
We identified that gene expression in neuronal cortical cells involves increased histone hyperacetylation on the Slc6a2 promoter, which is commensurate with the recruitment of SP1 and RNA Polymerase II and is inversely correlated with H3K9 trimethylation.
Data demonstrate that estrogen exerts significant modulatory effects on olfactory bulb function through modulation of tyrosine hydroxylase (zeige TH Proteine), dopamine transporter and norepinephrine transporter expression.
this is the first report to suggest that the norepinephrine transporter gene is one of many possible genetic factors influencing ethanol sensitivity in ILS, ISS, and LXS RI mouse strains
The effects of DAT (zeige SLC6A3 Proteine) KO in animal models of depression are larger than those produced by NET or SERT (zeige SLC6A4 Proteine) KO, and unlikely to be simply the result of the confounding effects of locomotor hyperactivity.
This gene encodes a member of the sodium symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
, norepinephrine transporter
, sodium-dependent noradrenaline transporter
, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
, solute carrier family 6 member 5
, NE transporter
, solute carrier family 6 member 2
, NaCl-dependent norepinephrine transporter
, neurotransmitter transporter, noradrenal
, transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
, norepinephrine plasma membrane transporter
, pulmonary norepinephrine plasma membrane transporter
, sodium-dependent noradrenaline transporter-like
, sodium- and chloride-dependent glycine transporter 2-like
, solute carrier family 6 (neurotransmitter transporter, glycine), member 5