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This locus encodes a sodium bicarbonate cotransporter. Zusätzlich bieten wir Ihnen SLC4A7 Antikörper (49) und viele weitere Produktgruppen zu diesem Protein an.
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rs3278 and rs3755652 stimulate an alternative transcription of the SLC4A7 gene, increasing the production of a defective transporter.
the disease-associated T allele of a new hypertension risk variant rs820430 linked increased hypertension risk through higher SLC4A7 expression, and rs820430 functioned as an enhancer of SLC4A7 transcription by allele distinctively increased c-Fos transcription factor binding.
this is the first work to demonstrate 3'UTR-mediated NBCn1 regulation, shows that p95HER2 regulates NBCn1 expression at multiple levels, and substantiates the central position of p95HER2-NBCn1 signaling in breast cancer.
The finding of a genotypic influence on SLC4A7 expression and pHi regulation in vascular smooth muscle cells provides an insight into the molecular mechanism underlying the association of variation at the SLC4A7 locus with blood pressure
Upregulation of NBCn1 during human breast carcinogenesis contributes to the characteristic acid distribution within human breast carcinomas.
A meta-analysis of genome-wide association studies of blood pressure and hypertension in Chinese identified three new loci (CACNA1D (zeige CACNA1D Proteine), CYP21A2 (zeige CYP21A2 Proteine), and MED13L) and a newly discovered variant near SLC4A7.
We demonstrate, for the first time, that 3 different pHi regulators responsible for acid extruding, i.e. NHE and NBC (zeige SLC4A4 Proteine), and MCT (zeige MCAT Proteine), are functionally co-existed in cultured radial artery smooth muscle cells.
The SLC4A7 variant rs4973768 is associated with breast cancer risk.
Simultaneous switching of the putative transmembrane segment (TM6) and TM12 of NBCe1 (zeige SLC4A4 Proteine) for those from NBCn1 severely impairs the expression of the transporter at the plasma membrane.
Data show that DeltaNErbB2 expression elicited Na(+), HCO(3)(-) cotransporter NBCn1 upregulation, Ser (zeige SIGLEC1 Proteine)(703)-phosphorylation of Na(+)/H(+) exchanger NHE1 (zeige SLC9A1 Proteine).
This study showed that extracellular acidification inhibits NBCn1 and NHE1 (zeige SLC9A1 Proteine) activity in VSMCs; NBCn1 is equivalently inhibited when pCO2 is raised or the bicarbonate level decreased. Lowering the sodium level inhibits NBCn1 and NHE1 (zeige SLC9A1 Proteine) markedly only below the typical physiological and pathophysiological range.
Under physiological conditions NBCn1 bicarbonateuptake raises VSMC pHi and promotes filopodia, VSMC migration, and hypertrophic inward remodelling. Propose that axial pHi gradients enhance VSMC migration whereas global acidification inhibits VSMC proliferation and media hypertrophy after carotid artery ligation.
NBCn1 facilitates acid extrusion from breast cancer tissue, maintains the alkaline intracellular environment and promotes aggressive cancer development and growth
The electroneutral Na+-HCO3- cotransporter (zeige SLC4A4 Proteine) NBCn1 plays an essential role in murine duodenal acid-base balance and colonic mucus layer build-up in vivo
Slc4a7 is a major regulator of basal and FSK-stimulated duodenal HCO3 secretion
Intracellular acidification of vascular smooth muscle and endothelial cells after knockout of NBCn1 inhibits nitric oxide-mediates signaling in isolated arteries and perturbs blood pressure regulation.
Damage of the sensory epithelia at the high frequency zone of the cochlea suggests that NBC3 may play an important physiological role in this region.
NBCn1 mediates the Na+-dependent bicarbonate transport important for pH(i) regulation in smooth muscle cells of mouse mesenteric, coronary, and cerebral small arteries.
most cases, hypoxia reduced NBCn1 levels by 20-50%, and NCBE (zeige SLC4A10 Proteine) levels by 15-40% in cerebral cortex, subcortex, cerebellum, and hippocampus, both after 14 and 28 days, and in both pups and adults.
We conclude that NBCn1 has a broad expression profile, supporting previous findings based on immunoreactivity, and suggest several new tissues where NBCn1 may be important.
This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described.
solute carrier family 4, sodium bicarbonate cotransporter, member 7
, sodium bicarbonate cotransporter 3
, sodium bicarbonate cotransporter 3-like
, bicarbonate transporter
, sodium bicarbonate cotransporter 2
, sodium bicarbonate cotransporter 2b
, solute carrier family 4 member 7
, Na-bicarbonate cotransporter
, NBC-like protein
, electroneutral sodium bicarbonate cotransporter 1