Sodium Channel, Nonvoltage-Gated 1 alpha Proteine (SCNN1A)

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Zusätzlich bieten wir Ihnen SCNN1A Antikörper (243) und SCNN1A Kits (12) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SCNN1A 25122 P37089
SCNN1A 6337 P37088
SCNN1A 20276 Q61180
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Showing 6 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,639.51
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human SCNN1a Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$625.39
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Escherichia coli (E. coli) Maus S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$749.00
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Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details

SCNN1A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Rat (Rattus)
Human ,
, ,
Mouse (Murine) ,
, ,

Weitere Proteine zu Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartnern

Human Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

  1. In the present study, the SCNN1G (zeige SCNN1G Proteine) gene was associated with 24-h urinary sodium excretion but was not related to blood pressure. The SCNN1A and SCNN1B (zeige SCNN1B Proteine) genes were not associated with blood pressure either.

  2. mutation in the extracellular domain of alphaENaC causes Liddle syndrome by increasing intrinsic channel activity.

  3. The mRNA and alpha-ENaC protein were overexpressed in platelets from hypertensive subjects versus control subjects.

  4. The derlin-1 (zeige DERL1 Proteine) pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  5. Data show that the expression of aquaporin (AQP) 1, AQP3, AQP5, epithelial Na+ channel (ENaC) and sodium potassium ATPase (Na-K-ATPase) are altered in patients with acute respiratory failure (ARF) due to diffuse alveolar damage (DAD), and the cause of DAD does not seem to influence the level of impairment of these channels.

  6. The data indicate that the Lhs1 chaperone selectively recognizes an immature form of alphaENaC, one which has failed to correctly assemble with the other channel subunits via its transmembrane domain.

  7. LEFTY2 (zeige LEFTY2 Proteine) regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1 (zeige SGK1 Proteine).

  8. Carriage of the p.W493R-SCNN1A polymorphism has been identified as a risk factor for bronchiectasis, but it is not invariably associated with the phenotype of a hyperactive ENaC channel in the lung.

  9. although subgroup analysis showed alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals, these meta-analysis results did not confirm such association overall; conclude that Alpha-ENaC T663A polymorphism might not be a risk factor for essential hypertension

  10. Four nonsynonymous amino acid variants in SCNN1A in nonwhite Cystic fibrosis (zeige S100A8 Proteine) patients with non-diagnostic CFTR (zeige CFTR Proteine) genotypes was identified.

Mouse (Murine) Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

  1. The derlin-1 (zeige DERL1 Proteine) pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  2. ENaC activity is regulated by calpain-2 (zeige CAPN2 Proteine) proteolysis of MARCKS (zeige MARCKS Proteine).

  3. nonselective cation channels ( channels consist of at least one alpha-ENaC and one or more acid-sensing ion channel (zeige ACCN2 Proteine) 1a (ASIC1a (zeige ACCN2 Proteine)) proteins.

  4. ENaC and ROMK (zeige KCNJ1 Proteine) channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4 (zeige WNK4 Proteine)(PHAII)-induced inhibition of ENaC and ROMK (zeige KCNJ1 Proteine) may contribute to the suppression of K(+) secretion in the tubules.

  5. Exosomal GAPDH (zeige GAPDH Proteine) from Proximal Tubule Cells Regulate ENaC Activity

  6. depletion of Kir4.1 (zeige KCNJ10 Proteine) stimulates the expression of ENaCbeta (zeige SCNN1B Proteine) and -gamma subunits in the cortical collecting duct

  7. LEFTY2 (zeige LEFTY2 Proteine) regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1 (zeige SGK1 Proteine).

  8. reducing ENaC expression in the connecting tubule induces clear pseudohypoaldosteronism type 1 symptoms during high dietary potassium loading

  9. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.

  10. PCSK9 (zeige PCSK9 Proteine)(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC under basal condition

Rabbit Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

Xenopus laevis Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

Guinea Pig Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

  1. Different subunits of ENaC expressed in various cell regions of the cochlea and endolymphatic sac (zeige ADCY10 Proteine) in distinct patterns may form the functional sodium channel to regulate the endolymph and maintain homeostasis in inner ear.

SCNN1A Protein Überblick

Protein Überblick

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit SCNN1A

  • sodium channel epithelial 1 alpha subunit (Scnn1a)
  • sodium channel epithelial 1 alpha subunit (SCNN1A)
  • sodium channel, nonvoltage-gated 1 alpha (Scnn1a)
  • sodium channel, non voltage gated 1 alpha subunit L homeolog (scnn1a.L)
  • alphaxENaC Protein
  • besc2 Protein
  • ENAC Protein
  • enaca Protein
  • ENaCalpha Protein
  • mENaC Protein
  • SCNEA Protein
  • scnn1 Protein
  • SCNN1A Protein

Bezeichner auf Proteinebene für SCNN1A

SCNEA , alpha-ENaC , alpha-NaCH , amiloride-sensitive sodium channel subunit alpha , epithelial Na(+) channel subunit alpha , epithelial sodium channel alpha subunit , nonvoltage-gated sodium channel 1 subunit alpha , sodium channel, nonvoltage-gated, type I, alpha , alpha ENaC-2 , amiloride-sensitive epithelial sodium channel alpha subunit , amiloride-sensitive sodium channel subunit alpha 2 , nasal epithelial sodium channel alpha subunit , sodium channel, nonvoltage-gated 1 alpha , ENaC alpha , amiloride-sensitive epithelial sodium channel , sodium channel, nonvoltage-gated, type I, alpha polypeptide , alpha ENaC , epithelial sodium channel ENaC alpha subunit , alpha cENaC 431 , amiloride-sensitve epithelial sodium channel alpha subunit , alpha-subunit renal epithelial sodium channel , epithelium sodium channel alpha subunit , sodium channel, nonvoltage-gated 1, alpha , amiloride-sensitive sodium channel alpha subunit

GENE ID SPEZIES
25122 Rattus norvegicus
6337 Homo sapiens
20276 Mus musculus
403650 Canis lupus familiaris
100009488 Oryctolagus cuniculus
397811 Xenopus laevis
282348 Bos taurus
396050 Gallus gallus
396608 Sus scrofa
443488 Ovis aries
451776 Pan troglodytes
100222046 Taeniopygia guttata
100484947 Ailuropoda melanoleuca
100014763 Monodelphis domestica
100135613 Cavia porcellus
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