Sodium Channel, Nonvoltage-Gated 1 alpha Proteine (SCNN1A)

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Zusätzlich bieten wir Ihnen SCNN1A Antikörper (244) und SCNN1A Kits (12) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SCNN1A 25122 P37089
SCNN1A 6337 P37088
SCNN1A 20276 Q61180
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Showing 6 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,506.65
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human SCNN1a Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$682.25
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Escherichia coli (E. coli) Maus S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$749.00
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Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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SCNN1A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Rat (Rattus)
Human ,
, ,
Mouse (Murine) ,
, ,

Weitere Proteine zu Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartnern

Human Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

  1. Here, we present the structure of human ENaC in the uncleaved state determined by single-particle cryo-electron microscopy. The ion channel is composed of a large extracellular domain and a narrow transmembrane domain

  2. Proteolytic cleavage activates epithelial sodium channel (SCNN) by removal of specific segments in finger domains of alpha and gamma subunits. Data suggest that the lower "palm" domain of SCNN1A is essential for allosteric activation of the SCNN heterotetramer [SCNN1A(1)-SCNN1B-SCNN1A(2)-SCNN1G].

  3. In the present study, the SCNN1G gene was associated with 24-h urinary sodium excretion but was not related to blood pressure. The SCNN1A and SCNN1B genes were not associated with blood pressure either.

  4. mutation in the extracellular domain of alphaENaC causes Liddle syndrome by increasing intrinsic channel activity.

  5. The mRNA and alpha-ENaC protein were overexpressed in platelets from hypertensive subjects versus control subjects.

  6. The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  7. Data show that the expression of aquaporin (AQP) 1, AQP3, AQP5, epithelial Na+ channel (ENaC) and sodium potassium ATPase (Na-K-ATPase) are altered in patients with acute respiratory failure (ARF) due to diffuse alveolar damage (DAD), and the cause of DAD does not seem to influence the level of impairment of these channels.

  8. The data indicate that the Lhs1 chaperone selectively recognizes an immature form of alphaENaC, one which has failed to correctly assemble with the other channel subunits via its transmembrane domain.

  9. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1.

  10. Carriage of the p.W493R-SCNN1A polymorphism has been identified as a risk factor for bronchiectasis, but it is not invariably associated with the phenotype of a hyperactive ENaC channel in the lung.

  11. although subgroup analysis showed alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals, these meta-analysis results did not confirm such association overall; conclude that Alpha-ENaC T663A polymorphism might not be a risk factor for essential hypertension

  12. Neither bronchodilatory response nor bicycling time trial performance after salbutamol was affected by genotype at rs2228576.

  13. Four nonsynonymous amino acid variants in SCNN1A in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was identified.

  14. The rs4149570 and rs7956915 polymorphisms of SCNN1A might play important roles in the susceptibility to respiratory distress syndrome, particularly in term infants.

  15. These results indicate that ENaC functions as a sensor for external Cd2+.

  16. The transcriptional expression of alpha, beta, and gamma subunits of ENaC was elevated in nasal polyp compared to nasal mucosa

  17. The long isoform of alphaENaC forms the structural basis of a channel with different activity and regulation, which may not be easily distinguishable in native tissue, but may underlie sodium hyperabsorption and salt sensitive differences in humans.

  18. ENaC regulates miR-101/miR-199a-3p during embryo implantation with the involvement of CREB phosphorylation.

  19. Five de novo mutations were identified in four genes (SCNN1A, KCNJ16, KCNB2, and KCNT1) in three Brugada syndrome patients

  20. ASIC1A and ENaCalpha form functional heterotrimers acting as ion channels.

Mouse (Murine) Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

  1. Casein kinase 2 phosphorylation is an important regulator of ENaC activity and sodium handling by the aldosterone sensitive distal nephron.

  2. N-linked glycans on each subunit are required for proper folding, maturation, surface expression, and function of the epithelial sodium channel.

  3. Based on the widespread presence of ENaC along the epididymis we suggest that mutations in ENaC subunits may also be associated with male infertility.

  4. Epithelial sodium channel alpha subunit knpckout (Scnn1a-/-} represses inward Na+ currents in culturedendothelial cell (ECs).

  5. These findings indicate that AMPK promotes the assembly of beta1Pix, 14-3-3 proteins, and Nedd4-2 into a complex that inhibits ENaC by enhancing Nedd4-2 binding to ENaC and its degradation.

  6. Aldosterone promotes increased interaction of NCC and ENaC.

  7. Increased ENAC alpha, beta and gamma subunits expression is associated with Lung disease.

  8. The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  9. ENaC activity is regulated by calpain-2 proteolysis of MARCKS.

  10. nonselective cation channels ( channels consist of at least one alpha-ENaC and one or more acid-sensing ion channel 1a (ASIC1a) proteins.

  11. ENaC and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC and ROMK may contribute to the suppression of K(+) secretion in the tubules.

  12. Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity

  13. depletion of Kir4.1 stimulates the expression of ENaCbeta and -gamma subunits in the cortical collecting duct

  14. Lack of epithelial sodium channel-mediated sodium transport along the nephron cannot be compensated for by other sodium channels and/or transporters, only by a high-sodium and reduced-potassium diet.

  15. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1.

  16. reducing ENaC expression in the connecting tubule induces clear pseudohypoaldosteronism type 1 symptoms during high dietary potassium loading

  17. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.

  18. PCSK9(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC under basal condition

  19. H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel

  20. 17beta-estradiol attenuates LPS-induced acute lung injury via PI3K/Akt/SGK1 mediated up-regulation of Scnn1a.

Rabbit Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

  1. mechanical stretch promotes expression

Xenopus laevis Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

  1. epithelial sodium channel activity is modulated by thiols

Guinea Pig Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) Interaktionspartner

  1. Different subunits of ENaC expressed in various cell regions of the cochlea and endolymphatic sac in distinct patterns may form the functional sodium channel to regulate the endolymph and maintain homeostasis in inner ear.

SCNN1A Protein Überblick

Protein Überblick

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit SCNN1A

  • sodium channel epithelial 1 alpha subunit (Scnn1a)
  • sodium channel epithelial 1 alpha subunit (SCNN1A)
  • sodium channel, nonvoltage-gated 1 alpha (Scnn1a)
  • sodium channel, non voltage gated 1 alpha subunit L homeolog (scnn1a.L)
  • alphaxENaC Protein
  • besc2 Protein
  • ENAC Protein
  • enaca Protein
  • ENaCalpha Protein
  • mENaC Protein
  • SCNEA Protein
  • scnn1 Protein
  • SCNN1A Protein

Bezeichner auf Proteinebene für SCNN1A

SCNEA , alpha-ENaC , alpha-NaCH , amiloride-sensitive sodium channel subunit alpha , epithelial Na(+) channel subunit alpha , epithelial sodium channel alpha subunit , nonvoltage-gated sodium channel 1 subunit alpha , sodium channel, nonvoltage-gated, type I, alpha , alpha ENaC-2 , amiloride-sensitive epithelial sodium channel alpha subunit , amiloride-sensitive sodium channel subunit alpha 2 , nasal epithelial sodium channel alpha subunit , sodium channel, nonvoltage-gated 1 alpha , ENaC alpha , amiloride-sensitive epithelial sodium channel , sodium channel, nonvoltage-gated, type I, alpha polypeptide , alpha ENaC , epithelial sodium channel ENaC alpha subunit , alpha cENaC 431 , amiloride-sensitve epithelial sodium channel alpha subunit , alpha-subunit renal epithelial sodium channel , epithelium sodium channel alpha subunit , sodium channel, nonvoltage-gated 1, alpha , amiloride-sensitive sodium channel alpha subunit

GENE ID SPEZIES
25122 Rattus norvegicus
6337 Homo sapiens
20276 Mus musculus
403650 Canis lupus familiaris
100009488 Oryctolagus cuniculus
397811 Xenopus laevis
282348 Bos taurus
396050 Gallus gallus
396608 Sus scrofa
443488 Ovis aries
451776 Pan troglodytes
100222046 Taeniopygia guttata
100484947 Ailuropoda melanoleuca
100014763 Monodelphis domestica
100135613 Cavia porcellus
Ausgewählte Anbieter für SCNN1A Proteine (SCNN1A)
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