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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Zusätzlich bieten wir Ihnen KCNN3 Antikörper (27) und und viele weitere Produktgruppen zu diesem Protein an.
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this is the first report to associate KCNN3 with poor prognosis and drug resistance in ovarian cancer (OC). The present findings indicated that KCNN3 is a potential prognostic marker and therapeutic target for OC.
SK current is increased via the enhanced activation of CaMKII (zeige CAMK2G Proteine) in patients with atrial fibrillation.
Data indicate that the inhibition of the Store Operated Calcium Entry (SOCE)-dependent colon cancer cell migration through SK3/TRPC1 (zeige TRPC1 Proteine)/Orai1 channel complex by the alkyl-lipid Ohmline may be a strategy to modulate Anti-EGFR (zeige EGFR Proteine) mAb action in metastatic colorectal cancer (mCRC).
Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival
Edelfosine is able to effectively inhibit migration and invasion of UC cells in vitro and in vivo in an SK3-dependent way, pointing towards a possible role for Edelfosine as an antiinvasive drug to effectively inhibit UC cell invasion and metastasis.
KCNN3 gene encodes small conductance calcium-activated potassium (SK) channel 3
Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction
Decreased SK3 expression in ganglionic bowel may explain the basis of persistent bowel symptoms in some patients following a properly performed pull-through operation for Hirschsprung's disease.
KCNN3 single-nucleotide polymorphism rs13376333 significantly increases the risk of Atrial Fibrillation.
SK3 channel and mitochondrial ROS (zeige ROS1 Proteine) mediate NADPH oxidase (zeige NOX1 Proteine)-independent NETosis induced by calcium influx.
SK channels (KCNN1 and KCNN3) provide a mechanism for sensing changes in intracellular Ca(2+) near the apical membrane, evoking hyperpolarization necessary for increasing the driving force for anion efflux following P2Y receptor activation [KCNN1].
Small conductance family member KCNN3 channel subtypes are activated in response to basolateral ATP challenge, essential in driving chloride secretion and thus fluid formation in the oviduct.
Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2 (zeige CA2 Proteine)+)-activated K(+) (SK) channels and reveals an important role for both SK2 (zeige PAPSS2 Proteine) and SK3 channels in normal regulation of serotinin (5-HT (zeige DDC Proteine)) neuronal excitability.
These results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP (zeige AGRP Proteine)/NPY (zeige NPY Proteine) neural activities and animals' feeding behavior and energy metabolism.
Dynamic coupling between TRPV4 (zeige TRPV4 Proteine) and Ca(2 (zeige CA2 Proteine)+)-activated SK1 (zeige SPHK1 Proteine)/3 and IK1 (zeige KCNN4 Proteine) K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (zeige KCNMA1 Proteine) in kidney collecting duct cells.
SK3 signaling microdomain modulates endothelial Ca(2+) dynamics, vascular tone, and blood pressure. SK3 knockout mice are hypertensive.
The data of this study implicated the family of KCNN genes in alcohol, nicotine, and drug addiction, and identify KCNN3 as a mediator of voluntary and excessive alcohol consumption
ovariectomy leads to a reduction in endothelial SK3 channel activity thereby reducing the SK3 contribution to endothelium-dependent hyperpolarization vasorelaxation.
Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.
Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 (zeige KCNN4 Proteine) channels
SK3 channel modulates placental vascular development and fetal health by altering VEGF (zeige VEGFA Proteine) signaling.
SK3 is functionally expressed in the distal nephron and collecting ducts where induction of TRPV4 (zeige TRPV4 Proteine)-mediated Ca2 (zeige CA2 Proteine)+ influx activates the channel.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, small conductance calcium-activated potassium channel protein 3
, small-conductance Ca2+-activated K+ channel 3
, calcium activated potassium channel SK3
, small conductance calcium-activated potassium channel 3