Small Conductance Calcium-Activated Potassium Channel Protein 3 Proteine (KCNN3)

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Zusätzlich bieten wir Ihnen KCNN3 Antikörper (27) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte KCNN3 KCNN3 54263 P70605
KCNN3 3782 Q9UGI6
KCNN3 140493  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 60 bis 65 Tage
$10,699.55
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,506.65
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$221.48
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KCNN3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Interaktionspartnern

Human Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Interaktionspartner

  1. SK3 expression was strongly reduced in the Hirschsprung disease patient intestines, both in the ganglionic and aganglionic bowel, compared to the control intestines.

  2. this is the first report to associate KCNN3 with poor prognosis and drug resistance in ovarian cancer (OC). The present findings indicated that KCNN3 is a potential prognostic marker and therapeutic target for OC.

  3. SK current is increased via the enhanced activation of CaMKII in patients with atrial fibrillation.

  4. Data indicate that the inhibition of the Store Operated Calcium Entry (SOCE)-dependent colon cancer cell migration through SK3/TRPC1/Orai1 channel complex by the alkyl-lipid Ohmline may be a strategy to modulate Anti-EGFR mAb action in metastatic colorectal cancer (mCRC).

  5. A splice variant SK3.2 was found in ventricular myocyte mitochondria and its mRNA expression was studied.

  6. Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival

  7. Edelfosine is able to effectively inhibit migration and invasion of UC cells in vitro and in vivo in an SK3-dependent way, pointing towards a possible role for Edelfosine as an antiinvasive drug to effectively inhibit UC cell invasion and metastasis.

  8. KCNN3 gene encodes small conductance calcium-activated potassium (SK) channel 3

  9. Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction

  10. Decreased SK3 expression in ganglionic bowel may explain the basis of persistent bowel symptoms in some patients following a properly performed pull-through operation for Hirschsprung's disease.

  11. KCNN3 single-nucleotide polymorphism rs13376333 significantly increases the risk of Atrial Fibrillation.

  12. There was no significant difference in the genotype distributions or allele frequencies of the SNP rs1131820 between AF patients and controls.

  13. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx.

  14. Reduced SK3 expression attenuates endometrial cell migration and is associated with unsuccessful pregnancy outcomes.

  15. Intermediate conductance Ca2+-activated K+ channels modulate human placental trophoblast syncytialization.

  16. Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.

  17. SK3 channel is activated in neuroblastoma cells by overexpression of human endogenous retrovirus W family envelope gene.

  18. Atrial miR-499 is significantly upregulated in AF, leading to SK3 downregulation and possibly contributing to the electrical remodeling in AF.

  19. study shows SK3 channels are localized in CD34(+) cells and not in smooth muscle cells and that expression of SK3 channels is higher in non-pregnant compared to pregnant myometrium; propose SK3 activators reduce myometrium contractility by modulating telocyte function; first report to provide evidence for possible role of SK3 channels in uterine telocytes

  20. Specific expression of hSK3 led to deficits in attention and sensory gating and heightened sensitivity to a psychomimetic drug

Pig (Porcine) Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Interaktionspartner

  1. SK channels (KCNN1 and KCNN3) provide a mechanism for sensing changes in intracellular Ca(2+) near the apical membrane, evoking hyperpolarization necessary for increasing the driving force for anion efflux following P2Y receptor activation [KCNN1].

Cow (Bovine) Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Interaktionspartner

  1. Small conductance family member KCNN3 channel subtypes are activated in response to basolateral ATP challenge, essential in driving chloride secretion and thus fluid formation in the oviduct.

KCNN3 Protein Überblick

Protein Überblick

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit KCNN3

  • potassium calcium-activated channel subfamily N member 3 (Kcnn3)
  • potassium calcium-activated channel subfamily N member 3 (KCNN3)
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (Kcnn3)
  • hSK3 Protein
  • KCa2.3 Protein
  • SK3 Protein
  • SKCA3 Protein

Bezeichner auf Proteinebene für KCNN3

SKCa 3 , SKCa3 , small conductance calcium-activated potassium channel protein 3 , small-conductance Ca2+-activated K+ channel 3 , SK3 , calcium activated potassium channel SK3 , small conductance calcium-activated potassium channel 3

GENE ID SPEZIES
54263 Rattus norvegicus
3782 Homo sapiens
490441 Canis lupus familiaris
397045 Sus scrofa
534180 Bos taurus
140493 Mus musculus
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