SLIT-ROBO rho GTPase Activating Protein 2 Proteine (SRGAP2)

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. Zusätzlich bieten wir Ihnen SRGAP2 Antikörper (34) und SRGAP2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SRGAP2 23380 O75044
SRGAP2 14270 Q91Z67
Ratte SRGAP2 SRGAP2 360840 D4A208;
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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SRGAP2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) Interaktionspartnern

Human SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) Interaktionspartner

  1. Results show that in high-grade, stage (zeige SRGAP3 Proteine)II osteosarcoma samples, expression of SRGAP2 was substantially reduced or absent in (zeige SRGAP3 Proteine)over half of the samples. Functional analysis provides further evidence that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.

  2. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.

  3. The extended F-BAR (F-BARx) domain of SRGAP2 (zeige SRGAP3 Proteine) generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 (zeige SRGAP3 Proteine) was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.

  4. human-specific duplication of SRGAP2 (zeige SRGAP3 Proteine) might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance

  5. This study illustrated that the role of SRGAP2 (zeige SRGAP3 Proteine) protein and its human-specific paralogs in human brain development and evolution.

  6. interlocus gene conversions in SRGAP2 (zeige SRGAP3 Proteine)

  7. SRGAP2 (zeige SRGAP3 Proteine) has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp (zeige MBL2 Proteine) of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.

  8. Results uncover a new function for ancestral SRGAP2 (zeige SRGAP3 Proteine) in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 (zeige SRGAP3 Proteine) in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex

  9. after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.

  10. srGAP2 (zeige SRGAP3 Proteine) arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) Interaktionspartner

  1. Results show that the effects of Srgap2 (zeige SRGAP3 Proteine) expression modulation in the murine OS cell lines support the hypothesis that SRGAP2 (zeige SRGAP3 Proteine) may have a role as a suppressor of metastases in osteosarcoma.

  2. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.

  3. The inverse F-BAR domain protein srGAP2 (zeige SRGAP3 Proteine) acts through srGAP3 (zeige SRGAP3 Proteine) to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (zeige ARHGEF16 Proteine) cells.

  4. Data show that srGAP2 (zeige SRGAP3 Proteine) is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.

  5. Study reports that srGAP2 (zeige SRGAP3 Proteine) negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.

Zebrafish SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) Interaktionspartner

  1. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration. Knockdown of SRGAP2a, a SRGAP2 (zeige SRGAP3 Proteine) ortholog in zebrafish, recapitulates podocyte foot process effacement.

SRGAP2 Protein Überblick

Protein Überblick

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.

Genbezeichner und Symbole assoziert mit SRGAP2

  • SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2)
  • SLIT-ROBO Rho GTPase activating protein 2 (Srgap2)
  • SLIT-ROBO Rho GTPase activating protein 2 (srgap2)
  • 9930124L22Rik Protein
  • AI448945 Protein
  • ARHGAP34 Protein
  • FBP2 Protein
  • Fnbp2 Protein
  • RGD1566016 Protein
  • srGAP2 Protein
  • srgap2a Protein
  • srGAP3 Protein
  • wu:fb47h12 Protein
  • zgc:136814 Protein

Bezeichner auf Proteinebene für SRGAP2

SLIT-ROBO Rho GTPase-activating protein 2 , formin binding protein 2 , formin-binding protein 2 , rho GTPase-activating protein 34 , FBP-27 , formin-binding protein 27 , LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 2 , SLIT-ROBO Rho GTPase activating protein 2a

GENE ID SPEZIES
23380 Homo sapiens
14270 Mus musculus
360840 Rattus norvegicus
100716665 Cavia porcellus
556198 Danio rerio
478949 Canis lupus familiaris
519843 Bos taurus
100050923 Equus caballus
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