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The protein encoded by SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily.
Showing 10 out of 92 products:
Human Monoclonal SLAMF6 Primary Antibody für CyTOF, FACS - ABIN4900064
Banerjee, Feuer, Barker et al.: Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous ... in Journal of virology 2007
Show all 4 Pubmed References
Human Polyclonal SLAMF6 Primary Antibody für WB - ABIN530287
Proust, Bertoglio, Gesbert: The adaptor protein SAP directly associates with CD3? chain and regulates T cell receptor signaling. in PLoS ONE 2012
Human Monoclonal SLAMF6 Primary Antibody für FACS - ABIN4897122
Kmiec, Iyer, Stürzel, Sauter, Hahn, Kirchhoff: Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance. in mBio 2016
Human Monoclonal SLAMF6 Primary Antibody für FACS - ABIN4897126
Sullivan, Jeha, Kang, Cheng, Rooney, Holladay, Bari, Schell, Tuggle, Pui, Leung: NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Human Monoclonal SLAMF6 Primary Antibody für FACS - ABIN4897128
Brunetta, Fogli, Varchetta, Bozzo, Hudspeth, Marcenaro, Moretta, Mavilio: The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. in Blood 2009
these results showed that the NTB-A/SAP (zeige APCS Antikörper) pathway regulates T-cell activation and restimulation-induced cell death during human tuberculosis
in addition to its established role in Invariant NKT (zeige SLC22A6 Antikörper)(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
our data reveal how SAP (zeige APCS Antikörper) nucleates a previously unknown signaling complex involving NTB-A and LCK (zeige LCK Antikörper) to potentiate restimulation-induced cell death of activated human T cells.
Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.
Data indicate that the dominance of the SLAMF3 (zeige LY9 Antikörper)/SLAMF6 pathway in inducing IL-17A (zeige IL17A Antikörper) production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A (zeige IL17A Antikörper) promoter.
SLAMF3 (zeige LY9 Antikörper) and SLAMF6 T cell surface expression and IL-17 (zeige IL17A Antikörper) levels significantly correlate with disease activity in systemic lupus erythematosus patients
Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 (zeige TH1L Antikörper) and IL-2 (zeige IL2 Antikörper) cytokine production
Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells.
regulation of interferon-gamma (zeige IFNG Antikörper) secretion, and not interleukin-4 (zeige IL4 Antikörper) in vitro, as well as inhibition of Th1 (zeige TH1L Antikörper) cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response
naive T cells regulate B cell survival in a SLAMF6-dependent manner
in addition to its established role in Invariant NKT (zeige CTSL1 Antikörper)(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans
CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT (zeige CTSL1 Antikörper) Cell Defects but Not T Follicular Helper Cell Defects.
study establishes a central role for germinal center B cell-specific CD84 (zeige CD84 Antikörper) and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity
When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta (zeige CD247 Antikörper) interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta (zeige CD247 Antikörper) dephosphorylation.
Ly108 expression distinguishes subsets of invariant NKT (zeige CTSL1 Antikörper) cells that help autoantibody production and secrete IL-21 (zeige IL21 Antikörper) from those that secrete IL-17 (zeige IL17A Antikörper) in lupus prone NZB/W mice.
Data indicate that Slamf6-H1 suppresses the spontaneous expansion of a unique osteopontin OPN (zeige SPP1 Antikörper)+ T follicular helper (TFH) cells.
Ly108 plays a role in the induction of PLZF (zeige ZBTB16 Antikörper) in developing thymocytes.
In the absence of SAP (zeige APCS Antikörper), signaling through the SLAM (zeige SLAMF1 Antikörper) family members Ly108 and 2B4 (zeige CD244 Antikörper) resulted in increased recruitment of the SHP-1 (zeige PTPN6 Antikörper) phosphatase, associated with altered SHP-1 (zeige PTPN6 Antikörper) localization and decreased activation of Src (zeige SRC Antikörper) kinases at the synapse.
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
SLAM family member 6
, activating NK receptor
, NTBA receptor
, natural killer-, T- and B-cell antigen
, lymphocyte antigen 108