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The protein encoded by RNF20 shares similarity with BRE1 of S. Zusätzlich bieten wir Ihnen RNF20 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal RNF20 Primary Antibody für ChIP, IP - ABIN151665
Shema, Tirosh, Aylon, Huang, Ye, Moskovits, Raver-Shapira, Minsky, Pirngruber, Tarcic, Hublarova, Moyal, Gana-Weisz, Shiloh, Yarden, Johnsen, Vojtesek, Berger, Oren: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. in Genes & development 2008
Show all 13 Pubmed References
The results demonstrate that Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B monoubiquitination.
RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB (zeige NFKB1 Antikörper) activity and attenuating the antitumoral T cell response.
RNF20 plays a critical role in the regulation of hepatic lipid metabolism by modulating the protein stability and transcriptional activity of SREBP1c (zeige SREBF1 Antikörper) during hormonal changes.
results suggested that RNF20 may play roles in adipocyte differentiation by stimulating ubiquitin-proteasome-dependent degradation of AP-2alpha (zeige TFAP2A Antikörper).
Bre1a-negative cells in the ventricular zone of early embryonic brains remain undifferentiated and are selected as self-renewing neural stem cells
model whereby cotranscriptional recruitment of Rnf20 at MLL (zeige MLL Antikörper)-fusion target genes leads to amplification of Dot1l (zeige DOT1L Antikörper)-mediated H3K79 methylation, thereby rendering leukemia cells dependent on Rnf20 to maintain their oncogenic transcriptional program
Loss of Bre1 (RNF20) disrupts gene silencing at telomeric chromatin. Most of the genomic instability in the Bre1-deficient cells is attributed to the formation of R-loops.
We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability
the observed defects in the radiation response of Bre1a/b-deficient cells
RNF20 depletion stabilizes the ZSCAN4 (zeige ZSCAN4 Antikörper) protein half-life, suggesting that RNF20 negatively regulates ZSCAN4 (zeige ZSCAN4 Antikörper) stability.
The effects of RNF20 on mammary tumorigenesis are subtype dependent: In basal-like cancers cells, RNF20 suppresses the NF-kappaB (zeige NFKB1 Antikörper)-dependent expression of cytokines, known to contribute to the growth of this tumor subtype.
The authors also show that the RING domains of RNF20 and RNF40 (zeige RNF40 Antikörper) can form a stable heterodimer that is active.
Manipulation of key H2Bub1 E3 ubiquitin ligases, RNF20, RNF40 (zeige RNF40 Antikörper) and BRCA1, in ovarian cancer cell line models modulated H2Bub1 levels, indicative of the role of these RING finger (zeige PCGF1 Antikörper) ligases in monoubiquitination of H2Bub1 in vitro
It was observed that RE-IIBP induces MEIS1 (zeige MEIS1 Antikörper)-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20.
A primary role for FACT in RNF20 recruitment chromatin remodeling for initiation of homologous recombination repair.
Together, these results indicate that human adenovirus E1A (zeige BCKDHA Antikörper) uses hBre1 to recruit the hPaf1 (zeige PAF1 Antikörper) complex in order to optimally activate viral early transcription by enhancing transcriptional elongation.
The ability of E1A (zeige BCKDHA Antikörper) to target hBre1 to simultaneously repress cellular IFN dependent transcription while activating viral transcription
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
, E3 ubiquitin-protein ligase BRE1A
, BRE1 E3 ubiquitin ligase homolog
, homolog of S. cerevisiae BRE1