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The protein encoded by RNF11 contains a RING-H2 finger motif, which is known to be important for protein-protein interactions.
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Human Polyclonal RNF11 Primary Antibody für ELISA, WB - ABIN565303
Chen, Zhou, Liu, Li, Azmi, Seth: The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. in Oncogene 2008
Show all 2 Pubmed References
Human Monoclonal RNF11 Primary Antibody für IF, ELISA - ABIN525793
Martin, Gruber, Keller, Zavolan: Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length. in Cell reports 2012
data suggest for the first time that the choice of binding partners for SMURF2 (zeige SMURF2 Antikörper) can sustain or repress TGFbeta (zeige TGFB1 Antikörper) signaling, and RNF11 may promote TGFbeta (zeige TGFB1 Antikörper)-induced cell migration.
Up-regulation of COPII components requires the transcriptional regulator RNF11, which localizes to early endosomes and appears additionally in the cell nucleus upon continuous EGF (zeige EGF Antikörper) stimulation.
RNF11 is at the center of a finally regulated system where it acts both as an adaptor and a modulator of itch-mediated control of ubiquitination events underlying membrane traffic.
Our data exemplifies the relevance of RNF11 and persistent NF-kappaB (zeige NFKB1 Antikörper) activation in Parkinson's disease
The negative influence that perturbation of RNF11 and SARA (zeige ZFYVE9 Antikörper) levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers.
RNF11 functions together with TAX1BP1 (zeige TAX1BP1 Antikörper) to restrict antiviral signaling and IFN-beta (zeige IFNB1 Antikörper) production.
RNF11 negatively regulates canonical NF-kappaB (zeige NFKB1 Antikörper) signaling in the nervous system.
Microglial RNF11 is a negative regulator of NF-kappaB (zeige NFKB1 Antikörper) signalling pathway and could be a strong potential target for modulating inflammatory responses in neurodegenerative diseases.
Data show that membrane anchoring through acylation is necessary for RNF11 to be post-translationally modified by the addition of several ubiquitin moieties.
overexpression of RNF11, through its interaction with Smurf2 (zeige SMURF2 Antikörper), can restore TGFbeta (zeige TGFB1 Antikörper) responsiveness in transfected tumor cells
We first demonstrate that a splice site variant in the RING finger protein 11 (RNF11) gene accounts for ~40% of cases of stunted growth in cattle
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).
RING finger protein 11
, NEDD4 WW domain-binding protein 2
, sid 1669