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The protein encoded by RLIM is a RING-H2 zinc finger protein. Zusätzlich bieten wir Ihnen RLIM Proteine (5) und und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 54 products:
Human Polyclonal RLIM Primary Antibody für WB - ABIN1881751
Jonkers, Barakat, Achame, Monkhorst, Kenter, Rentmeester, Grosveld, Grootegoed, Gribnau: RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation. in Cell 2009
Show all 5 Pubmed References
Human Monoclonal RLIM Primary Antibody für IF, IP - ABIN565536
Zhou, Drabsch, Dekker, de Vinuesa, Li, Hawinkels, Sheppard, Goumans, Luwor, de Vries, Mesker, Tollenaar, Devilee, Lu, Zhu, Zhang, Dijke: Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-? signalling. in Nature communications 2014
Show all 3 Pubmed References
Results from a study on gene expression variability markers in early-stage human embryos shows that RLIM is a putative expression variability marker for the 3-day, 8-cell embryo stage.
missense mutation in RLIM gene was identified in four males with intellectual disability from a three-generation family.
RNF12 is a novel positive regulator of p53 (zeige TP53 Antikörper) pathway and an external E3 ubiquitin ligase (zeige MUL1 Antikörper) for MDM2 (zeige MDM2 Antikörper) destruction.
Rlim is a novel regulator of Stathmin (zeige STMN1 Antikörper) protein in a ubiquitin-dependent manner, and represents a new pathway for malignant phenotype turnover by modulating the level of Stathmin (zeige STMN1 Antikörper) protein in human osteosarcomas.
hus (zeige CFH Antikörper) regulated nucleocytoplasmic shuttling of RLIM/Rnf12 coordinates cellular compartments during mammary alveolar cell survival
TP53 (zeige TP53 Antikörper) does not directly bind to the RLIM promoter, it physically interacts with and prevents the binding of Sp1 (zeige PSG1 Antikörper) to the RLIM promoter.
these results indicated that RLIM is an important positive regulator in TGF-beta (zeige TGFB1 Antikörper) signaling pathway and cell migration.
RLIM represents a new pathway for telomere maintenance by modulating the level of TRF1 (zeige TERF1 Antikörper) at telomeres.
These findings provide evidence for a dose-dependent role of RNF12 in the XCI counting and initiation process.
These findings show that control of Lhx2 (zeige LHX2 Antikörper) function by Ldb1 (zeige LDB1 Antikörper) and Rnf12 underpins the coordinated differentiation of neurons and Muller glia in postnatal retina.
These results reveal crucial roles of Rlim for the maintenance of high Xist RNA levels, Xist clouds and X-silencing in female embryos at blastocyst stages, while initial Xist expression appears Rlim-independent.
In late preimplantation, Oct4 (zeige POU5F1 Antikörper) served as a chromatin opener to create transcriptional permissive states at Xm-Xist/Tsix genomic loci. In parthenogenetic embryos, Rnf12 overdose caused Xm-Xist derepression via Xm-Tsix repression; physiological Rnf12 levels were essential for Xm-Xist silencing maintenance in fertilized embryos.
high RNF12 levels may contribute to the specific activation of maternal Xist in XpDeltaXist female ROSI embryos, but upregulation of additional Xp derived factors and/or the specific epigenetic constitution of the round spermatid-derived Xp are expected to be more critical
results provide evidence that RLIM is dispensable for rXCI, indicating that in mice an RLIM-independent mechanism activates Xist in the embryo proper
The trans-activator RNF12 and cis (zeige CISH Antikörper)-acting elements effectuate X chromosome inactivation independent of X-pairing.
RNF12 causes REX1 (zeige REXO1 Antikörper) breakdown through dose-dependent catalysis, thereby representing an important pathway to initiate X-chromosome inactivation
Results provide strong evidence that RLIM/Rnf12 is required for the survival of differentiated milk-producing alveolar cells in pregnant and lactating female mice.
The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells.
RNF12 is essential for initiation of XCI and is mainly involved in the regulation of Xist.
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified.
E3 ubiquitin-protein ligase RLIM
, E3 ubiquitin-protein ligase RNF12
, LIM domain-interacting RING finger protein
, RING finger LIM domain-binding protein
, renal carcinoma antigen NY-REN-43
, ring finger protein 12
, ring zinc finger LIM domain binding protein
, ring zinc finger protein NY-REN-43antigen
, Hoxa1 regulated
, LIM domain interacting RING finger protein