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ROPN1L encodes a member of the ropporin family. Zusätzlich bieten wir Ihnen Rhophilin Associated Tail Protein 1-Like Antikörper (62) und Rhophilin Associated Tail Protein 1-Like Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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Sp17 and ASP cancer/testis antigens were found in ciliated cells of four ciliated hepatic foregut cysts (CHFCs). Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas.
Single nucleotide polymorphisms in ROPN1L gene is associated with breast cancer.
Mutations in ROPN1 and ROPN1L can cause defects in fibrous sheath integrity, sperm motility, and PKA-dependent signaling processes, leading to male infertility.
The beat frequency of cilia from mice lacking ASP is significantly slower than wild type, indicating that ASP signaling may regulate ciliary motility.
Northern blot analysis of testis RNA from 5-, 15-, 25-, and 40-day-old mice showed expression of the ASP gene and in situ hybridization analysis localized the ASP mRNA to the germ cell compartment of the seminiferous tubules in the testis
This gene encodes a member of the ropporin family. The encoded protein is a sperm protein. It interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Type II regulatory subunit of cAMP-dependent protein kinase (PKARII) also binds to this helix domain of AKAP3, which allows PKARII to be targeted to specific subcellular compartments. It is suggested that sperm contains several proteins that bind to AKAPs in a manner similar to PKARII, and this encoded protein may be one of them. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
, ropporin-1-like protein
, AKAP-associated sperm protein
, A-kinase anchoring protein-associated sperm protein
, ROPN1-like protein
, radial spoke head 11 homolog