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RBBP5 encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. Zusätzlich bieten wir Ihnen Retinoblastoma Binding Protein 5 Antikörper (69) und viele weitere Produktgruppen zu diesem Protein an.
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role of RBQ3 in the development of multiple myeloma
This study demonstrated that RBQ3 might play an important role in glioma, and RBQ3 inhibitors might be novel anti-tumor agents.
The identified components revealed factors involved in histone methylation and cell cycle control and include Ash2L (zeige ASH2L Proteine), RbBP5, WDR5 (zeige WDR5 Proteine), HCF-1 (zeige HCFC1 Proteine), DBC-1, and EMSY (zeige C11orf30 Proteine).
Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L (zeige ASH2L Proteine) heterodimer.
Data indicate that MLL1 methylates Ash2L (zeige ASH2L Proteine) in the absence of histone H3 (zeige HIST3H3 Proteine), but only when assembled within a complex with WDR5 (zeige WDR5 Proteine) and RbBP5.
structural and biochemical analyses reveal a basic surface on Ash2L (zeige ASH2L Proteine) as the RbBP5-binding interface, and this interface is crucial for both RbBP5 binding and MLL1 methyltransferase activity regulation
Results show that Depletion of CHD8 enhances HOXA2 (zeige HOXA2 Proteine) expression and a loss of the WDR5 (zeige WDR5 Proteine)/Ash2L (zeige ASH2L Proteine)/RbBP5 subcomplex.
analysis of menin's role as a tumor suppressor and binding sites of Rbbp5 and MLL1
a phosphorylation switch on RbBP5 stimulates WRAD complex formation and significantly increases KMT2 (lysine [K] methyltransferase 2 (zeige DNMT1 Proteine)) enzyme methylation rates
Characterization of a novel WDR5 (zeige WDR5 Proteine)-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 (zeige HIST3H3 Proteine) lysine 4 by mixed lineage leukemia protein-1.
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
retinoblastoma binding protein 5
, retinoblastoma-binding protein 5-like
, SWD1, Set1c WD40 repeat protein, homolog
, retinoblastoma-binding protein 5
, retinoblastoma-binding protein RBQ-3