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RBM8A encodes a protein with a conserved RNA-binding motif. Zusätzlich bieten wir Ihnen RNA Binding Motif Protein 8A Proteine (13) und RNA Binding Motif Protein 8A Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal RBM8A Primary Antibody für WB - ABIN188636
Barbosa, Haque, Fiorini, Barrandon, Tomasetto, Blanchette, Le Hir: Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. in Nature structural & molecular biology 2012
Show all 3 Pubmed References
Human Polyclonal RBM8A Primary Antibody für ICC, IF - ABIN4349641
Singh, Wachsmuth, Kulozik, Gehring: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. in RNA biology 2013
Human Monoclonal RBM8A Primary Antibody für ICC, FACS - ABIN108586
Kataoka, Yong, Kim, Velazquez, Perkinson, Wang, Dreyfuss: Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. in Molecular cell 2000
Results demonstrated that RBM8A is highly expressed in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)), and patients with lower RBM8A expression level had longer overall survival and progression free survival. Also, results indicate that RBM8A promotes invasion and metastasis via epithelial-mesenchymal transition signaling pathway.
Y14 may selectively and differentially modulate protein biosynthesis.
this data suggests a novel role of RBM8a in the regulation of neurodevelopment.
Mutations of RBM8A and TBX6 (zeige TBX6 Antikörper) are associated with disorders of the mullerian ducts.
It was demonstrated that Rbm8a is an essential neurogenesis regulator in embryonic cortical development.
Depletion of RNA-binding protein (zeige PTBP1 Antikörper) RBM8A (Y14) causes cell cycle deficiency and apoptosis in human tumor cells.
Y14 positively regulates signals for TNF-alpha (zeige TNF Antikörper)-induced IL-6 (zeige IL6 Antikörper) production at multiple steps beyond an exon junction complex protein.
Y14 mutants, which are deficient in binding to Magoh (zeige MAGOH Antikörper), could still be localized to the nucleus, suggesting the existence of both the nuclear import pathway and function for Y14 unaccompanied by Magoh (zeige MAGOH Antikörper)
Data show that Y14 interacts directly with the decapping factor Dcp2 (zeige DCP2 Antikörper) and the 5' cap structure of mRNAs via different but overlapping domains.
findings show that the two regulatory SNPs result in diminished RBM8A transcription in vitro and that Y14 expression is reduced in platelets from individuals with thrombocytopenia with absent radii (TAR)
our data demonstrate that miR (zeige MLXIP Antikörper)-29a regulates the proliferation and differentiation of RPCs by directly targeting Rbm8a, providing us with a better understanding of the molecular mechanisms that govern RPC (zeige RTCD1 Antikörper) proliferation and differentiation.
Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a (zeige GSK3a Antikörper) phosphorylate splicing factors (Rbm8a, Srsf9 (zeige SFRS9 Antikörper), and Psf (zeige IL-3 Antikörper)) and nucleolar proteins (Npm1 (zeige GJA1 Antikörper) and Phf6 (zeige PHF6 Antikörper)); Gsk3b/Gsk3a (zeige GSK3a Antikörper) are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3 (zeige GSK3a Antikörper); Rbm8a = RNA binding motif protein 8a; Srsf9 (zeige SFRS9 Antikörper) = splicing factor (zeige SLU7 Antikörper), arginine-serine-rich 9; Psf (zeige IL-3 Antikörper) = replication protein Psf (zeige IL-3 Antikörper); Npm1 (zeige GJA1 Antikörper) = nucleophosmin 1 (zeige NPM1 Antikörper); Phf6 (zeige PHF6 Antikörper) = PHD finger protein 6 (zeige PHF6 Antikörper))
we first show that Eif4a3 (zeige EIF4A3 Antikörper) haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh (zeige MAGOH Antikörper) and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53 (zeige TP53 Antikörper), significantly rescues microcephaly of all 3 EJC mutant
This is the first study that demonstrates the key role of RBM8a on the emotional behaviors in mice.
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B\; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.
RNA binding motif protein 8A
, RNA-binding motif protein 8A
, RNA-binding protein 8A
, Ribonucleoprotein RBM8A
, RNA binding motif protein 8B
, RNA-binding protein Y14
, binder of OVCA1-1
, ribonucleoprotein RBM8
, ribonucleoprotein RBM8A
, RNA binding motif protein 8
, RNA-binding motif protein 8A-A
, RNA-binding protein 8A-A
, Ribonucleoprotein RBM8A-A