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Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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The authors demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1 (zeige PRMT1 Antikörper)) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4 (zeige CNOT4 Antikörper)).
OTT1 regulates the alternative splicing of Mpl- (zeige MPL Antikörper)TR, a truncated isoform of c-Mpl, (zeige MPL Antikörper) which modulates Thrombopoietin- (zeige THPO Antikörper)mediated signaling.
RBM15 does indeed play a critical role in the survival of chronic myelogenous leukemia (CML) cells, which may have potential application in designing molecular therapies for CML treatment.
both Rbm15 and the leukemogenic Rbm15-Mkl1 (zeige MKL1 Antikörper) fusion protein interact with the Setd1b (zeige SETD1B Antikörper) histone H3 (zeige HIST3H3 Antikörper)-Lys4 methyltransferase
A four-way variant translocation originating the RBM15-MKL1 (zeige MKL1 Antikörper) fusion gene is associated with acute megakaryoblastic leukemia.
HHV-8 ORF57 interacts with RBM15 and OTT3 (zeige RBM15B Antikörper) to promote expression of viral intronless genes.
Fusion with MKL1 (zeige MKL1 Antikörper) protein in acute myeloid leukemi.
functional and spatial changes of OTT and BSAC (zeige MKL1 Antikörper) caused by the fusion might perturb their functions, culminating in the development of acute megakaryoblastic leukemia.
The deregulated activation of MAL-dependent and -independent promoters results in tissue-specific functions of OTT-MAL.[OTT-MAL]
Rbm15 is required for Xist-mediated silencing. Rbm15 is important for efficient deposition of H3K27me3 on the inactive chromosome.
Rbm15 regulates the alternative splicing of Mpl (zeige MPL Antikörper)-TR, a truncated isoform of c-Mpl (zeige MPL Antikörper), which modulates Thrombopoietin (zeige THPO Antikörper)-mediated signaling.
Rbm15 is differentially expressed during hematopoiesis and may act to inhibit myeloid differentiation in hematopoietic cells via a mechanism that is mediated by stimulation of Notch (zeige NOTCH1 Antikörper) signaling via RBPJkappa.
Rbm15 has pleiotropic roles in hematopoietic development.
c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development.
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005
RNA binding motif protein 15
, putative RNA-binding protein 15-like
, RNA-binding motif protein 15
, one twenty two protein
, one twenty-two
, one-twenty two protein 1
, putative RNA-binding protein 15