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RBM10 encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif.
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Human Polyclonal RBM10 Primary Antibody für ICC, IF - ABIN4349575
Jackson, Du, Janesko-Feldman, Vagni, Dezfulian, Poloyac, Jackson, Clark, Kochanek: The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015
Human Polyclonal RBM10 Primary Antibody für EIA, WB - ABIN954474
Johnston, Teer, Cherukuri, Hansen, Loftus, Chong, Mullikin, Biesecker: Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate. in American journal of human genetics 2010
Show all 3 Pubmed References
The well-known high-fidelity RNA splice site recognition by RBM10, and probably by RBM5 (zeige RBM5 Antikörper) and RBM6 (zeige RBM6 Antikörper), can thus be largely rationalized by a cooperative binding action of RRM and ZnF (zeige ZNF629 Antikörper) domains
Our work has not only expanded the number of pre-mRNA targets for RBM10, but identified RBM10 as a novel regulator of SMN2 (zeige SMN1 Antikörper) alternative inclusion.
RBM10 functions as a splicing regulator (zeige PTBP2 Antikörper) using two RNA-binding units with different specificities to promote exon skipping.
RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5 (zeige RBM5 Antikörper)) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD).
results provide evidence that RBM10 expression, in RBM5 (zeige RBM5 Antikörper)-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 (zeige RBM5 Antikörper) expression in clinical samples may therefore hold prognostic and/or potentially predictive value
RBM10-TFE3 (zeige TFE3 Antikörper) is a recurrent gene fusion in Xp11 translocation renal cell carcinoma (zeige MOK Antikörper).
Xp11 translocation renal cell carcinomas with RBM10-TFE3 (zeige TFE3 Antikörper) gene fusion demonstrating melanotic features and overlapping morphology with t(6;11) RCC (zeige XRCC1 Antikörper).
RBM10-TFE3 (zeige TFE3 Antikörper) fusion variant (from chromosome X paracentric inversion), therefore, appears to be a recurrent molecular event in Xp11.2 RCCs. RBM10-TFE3 (zeige TFE3 Antikörper) fusion should be added in the list of screened fusion transcripts in targeted molecular diagnostic multiplex RT-PCR
RBM10 is a tumor suppressor that represses Notch (zeige NOTCH1 Antikörper) signaling and cell proliferation through the regulation of NUMB (zeige NUMB Antikörper) alternative splicing
Src (zeige SRC Antikörper) family tyrosine kinase (zeige TXK Antikörper) signaling may regulate FilGAP (zeige ARHGAP24 Antikörper) through association with RBM10
These results demonstrate a role for RBM10 in the regulation of alternative splicing in two cell models of mouse early development and suggests that mutations in RBM10 could lead to splicing changes that affect normal palate development and cause human disease.
Expression of Rbm5 (zeige RBM5 Antikörper) and Rbm10 RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
S1-1 constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner; upon globally reducing RNA polymerase II (zeige 0 Antikörper) transcription, S1-1 nuclear bodies enlarge and decrease in number.
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.
RNA binding motif protein 10
, RNA-binding protein 10-like
, RNA-binding protein 10
, RNA-binding protein S1-1
, g patch domain-containing protein 9
, RNA-binding motif protein 10
, S1-1 protein from liver