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Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
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Human Polyclonal RAD51D Primary Antibody für ICC, IF - ABIN151188
Hinz, Tebbs, Wilson, Nham, Salazar, Nagasawa, Urbin, Bedford, Thompson: Repression of mutagenesis by Rad51D-mediated homologous recombination. in Nucleic acids research 2006
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Human Monoclonal RAD51D Primary Antibody für ICC, IF - ABIN151303
Kawabata, Saeki: Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the rec A/RAD51 gene family. in Biochemical and biophysical research communications 1999
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Monoclonal RAD51D Primary Antibody für IF, WB - ABIN534118
Fan, Kumaravel, Jalali, Marrano, Squire, Bristow: Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. in Cancer research 2004
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Human Polyclonal RAD51D Primary Antibody für ELISA - ABIN268788
Pittman, Weinberg, Schimenti: Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. in Genomics 1998
RNF138 (zeige RNF138 Antikörper) is a newly identified regulatory component of the HR mediated DNA repair pathway that has implications toward understanding how ubiquitination modifies the functions of the RAD51 (zeige RAD51 Antikörper) paralog protein complex
Cells deficient in RAD51D (a RAD51 (zeige RAD51 Antikörper) paralogue) are extremely sensitive to 6-thioguanine.
RAD51D protects against MLH1 (zeige MLH1 Antikörper)-dependent cytotoxic responses to O(6)-methylguanine
a fragment of Rad51B (zeige Rad51B Antikörper) containing amino acid residues 1-75 interacts with the C-terminus and linker of Rad51C (zeige RAD51C Antikörper), residues 79-376, and this region of Rad51C (zeige RAD51C Antikörper) also interacts with mRad51D and Xrcc3 (zeige XRCC3 Antikörper)
Findings support a crucial role for mammalian RAD51D in normal development, recombination, and maintaining mammalian genome stability.
These cell-based studies are the first evidence that ATP binding and hydrolysis by RAD51D are required for efficient HR repair of DNA interstrand crosslinks.
Rad51d alternative splice variants potentially modulate mechanisms of homologous recombination by sequestering either RAD51C or XRCC2
Interactions of four candidate proteins (SFPQ, NONO, MSH2 and mini chromosome maintenance protein 2) were confirmed by Western blot analysis of co-precipitation eluates and were also verified to form ex vivo complexes with RAD51D.
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA (By similarity).
DNA repair protein RAD51 homolog 4
, RAD51-like 3