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results suggest that LRRK2 kinase activity functions as a Rab5b GTPase activating protein (zeige RASA1 Proteine) and thus, negatively regulates Rab5b signalling
combined genetic association studies in women from China/Netherlands/United States: Data suggest that an SNP in RAB5B locus (rs705702) and SNPs in other proteins are associated with polycystic ovary syndrome across ethnic differences. [META-ANALYSIS]
study shows expression of GTPase (zeige RACGAP1 Proteine)-deficient Rab5b in NRK (zeige NRK Proteine) cells results in sequential formation of 3 distinct types of endosomes; study suggests regulatory role for Rab5 (zeige RAB5A Proteine) in early & late endocytic pathway of membrane trafficking in coordination with PI(3 (zeige PI3 Proteine))K
Results suggest that LRRK2, in conjunction with its interaction with Rab5b, plays an important role in synaptic function by modulating the endocytosis of synaptic vesicles.
suppression of Rab5A (zeige RAB5A Proteine) or 5B hampered the degradation of EGFR (zeige EGFR Proteine)
clear effect of subcutaneous zoledronic acid administration in vivo on the prenylation of Rab1A (zeige RAB1A Proteine), Rab5B, Rab7A (zeige RAB7A Proteine) and Rab14 (zeige RAB14 Proteine) in mouse peritoneal macrophages, confirming that systemic treatment with bisphosphonate drug can inhibit prenylation in myeloid cells in vivo outside the skeleton.
Protein transport. Probably involved in vesicular traffic (By similarity).
RAB5A member RAS oncogene family
, ras-related protein Rab-5B
, RAB5B, member RAS oncogene family