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Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009].. Zusätzlich bieten wir Ihnen RAB31 Antikörper (33) und viele weitere Produktgruppen zu diesem Protein an.
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the role of Rab31 in cancer progression, is reported.
this study provides the evidence of Rab31 overexpression in HCC (zeige FAM126A Proteine), and Rab31 is potentially used as a novel biomarker of poor prognosis in patients with HCC (zeige FAM126A Proteine). PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)/Bcl-2 (zeige BCL2 Proteine)/BAX (zeige BAX Proteine) axis was involved in Rab31-promoting HCC (zeige FAM126A Proteine) progression.
Data indicate that early endosome antigen 1 (EEA1 (zeige EEA1 Proteine)) is important for the small GTPase (zeige RACGAP1 Proteine) Rab31-mediated enhancement of ligand-bound EGF receptor (EGFR (zeige EGFR Proteine)) endocytic trafficking.
MUC1 (zeige MUC1 Proteine)-C and Rab31 function in an autoinductive loop that contributes to overexpression of MUC1 (zeige MUC1 Proteine)-C in breast cancer cells.
Overexpression of rab31 in breast cancer cells leads to a switch from an invasive to a proliferative phenotype as indicated by an increased cell proliferation, reduced adhesion and invasion in vitro, and a reduced capacity to form lung metastases in vivo.
Neither UPARwt, nor UPAR (zeige PLAUR Proteine)-del4/5 nor RAB31 mRNA expression levels were found to be prognostic markers in advanced ovarian cancer.
RIN3 (zeige RIN3 Proteine) specifically acts as a GEF (zeige SLC2A4RG Proteine) for Rab31.
Thus, Rab22B may have a role in anterograde exit from the trans-Golgi network .
uPAR (zeige PLAUR Proteine)-del4/5 and rab31 mRNA represent independent prognostic markers in breast cancer and may be components of different, but possibly associated, tumor-relevant signaling pathways.
Rab22B possibly plays role in regulating e (zeige NES Proteine)pidermal growth factor receptor (EGFR) and mannose 6-phosphate receptor (M6PR) transport into late endosomes.
Rab31, with APPL2 (zeige APPL2 Proteine) as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (zeige AKT1 Proteine) signaling in macrophages.
a previously unrecognised role for Rab31 in influencing the differentiation and fate of neural progenitor cells
Insulin (zeige INS Proteine) recruits the CIP4/Gapex-5 (zeige GAPVD1 Proteine) complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 (zeige SLC2A4 Proteine) vesicles to translocate to the cell surface, where Glut4 (zeige SLC2A4 Proteine) docks and fuses to transport glucose into the cell.
Rab22B is exceptionally enriched in nestin (zeige NES Proteine) and RC2-positive radial glia of the embryonic mouse brain. In the adult brain, Rab22B is rather specifically expressed in glial fibrillary acidic protein (GFAP (zeige GFAP Proteine))-positive mature astrocytes.
Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002
RAB31, member RAS oncogene family
, ras-related protein Rab-31
, ras-related protein Rab-22B
, GTP-binding protein Rab0
, monomeric GTP-binding protein