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RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Zusätzlich bieten wir Ihnen RAB25 Antikörper (91) und viele weitere Produktgruppen zu diesem Protein an.
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Rab25 is amplified and enhances aggressiveness in luminal B cancers while in claudin-low tumors, Rab25 is lost indicating possible anti-tumor functions
Our results suggest that Rab25 tumourigenic potential and chemoresistance relies on HIF1 activity in aggressive and metastatic ovarian cancer
The results from this analysis indicated that Rab11a (zeige RAB11A Proteine), Rab11c(Rab25) and Rab14 (zeige RAB14 Proteine) were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line.
Data show that Rab25 is responsible for RIN1 (zeige RIN1 Proteine)-induced EGFR (zeige EGFR Proteine) signaling and tumor malignancy in clear cell renal cell carcinoma (zeige MOK Proteine) cell.
Promoter methylation results in downregulation of RAB25 expression in oropharyngeal squamous cell carcinoma. Decreased Rsb25 expression is associated with lymph node metastasis.
Rab25 may act as a tumor promoter.
Rab25 was upregulated in hepatocellular carcinoma tissues and cells compared with normal liver tissues and cell lines. Rab25 overexpression correlated with advanced tumor stage and nodal metastasis.Rab25 depletion blocked cell growth rate, inhibited colony formation, downregulated AKT (zeige AKT1 Proteine) phosphorylation, inhibited the Wnt (zeige WNT2 Proteine) signaling pathway and its target genes, and negatively regulated the invading ability of HCC (zeige FAM126A Proteine) cells.
Data show that both rab G-Protein RAB25 and RNA-binding protein ESRP1 were suppressed by transcription factor ZEB1, which was in turn regulated via epigenetic mechanisms.
Rab25 expression is a potential prognostic index for advanced NSCLC patients and its inhibition may improve chemosensitization in NSCLC treatment.
These results showed that high levels of Rab25 expression were significantly correlated with renal cell carcinoma (zeige MOK Proteine) invasion classification (P < 0.01), lymph-node metastasis (P < 0.001), and pathological stage (P < 0.01).
Our results strongly confirm the tumorigenic role of Rab25 in tobacco carcinogen-induced lung cancer and demonstrate aerosol delivery of shRab25 as a therapeutic target for lung cancer treatment
Autophagy regulates turnover of lipid droplets via ROS (zeige ROS1 Proteine)-dependent Rab25 activation in hepatic stellate cells.
a Grhl2 (zeige GRHL2 Proteine)/Ovol2 (zeige OVOL2 Proteine) network controls Cldn4 (zeige CLDN4 Proteine) and Rab25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
tight regulation of CCN3 (zeige NOV Proteine) expression is necessary for normal cortical neuronal connectivity during development, and RAB25 negatively regulates neuronal differentiation as a downstream effector of CCN3 (zeige NOV Proteine)
the results indicate that Grhl2 (zeige GRHL2 Proteine) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (zeige CLDN3 Proteine) and Cldn4 (zeige CLDN4 Proteine), as well as of Rab25, which increases the Cldn4 (zeige CLDN4 Proteine) protein and its localization at TJs
Rab25 may function as a tumor suppressor in intestinal epithelial cells through regulation of protein trafficking to the cell surface.
RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Members of the RAB11 subfamily, including RAB25, control the return of internalized membrane-associated moieties to the cell surface (Caswell et al., 2007
RAB25, member RAS oncogene family
, ras-related protein Rab-25
, Ras-related protein Rab-25
, small GTP-binding protein