anti-Proteoglycan 4 (PRG4) Antikörper

The protein encoded by PRG4 is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. Zusätzlich bieten wir Ihnen Proteoglycan 4 Kits (27) und Proteoglycan 4 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PRG4 10216 Q92954
PRG4 289104  
PRG4 96875 Q9JM99
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Top anti-Proteoglycan 4 Antikörper auf antikoerper-online.de

Showing 10 out of 39 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB   0.2 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details
Human Maus Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$537.17
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Human Kaninchen Unkonjugiert ICC, IHC (p), WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$727.83
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$390.50
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Human Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Kaninchen Unkonjugiert WB Figure 1 shows a Western blot of Lubricin in human recombinant Lubricin using ABIN261551. Western Blot: Proteoglycan 4 Antibody [ABIN2615513] - Analysis of 3ug of non-reduced human synovial fluid per well onto a SDS-PAGE gel. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen FITC IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details

PRG4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Proteoglycan 4 Antikörper

  1. Human Polyclonal Proteoglycan 4 Primary Antibody für ELISA, IHC - ABIN438915 : Leonardi, Rusu, Loreto, Loreto, Musumeci: Immunolocalization and expression of lubricin in the bilaminar zone of the human temporomandibular joint disc. in Acta histochemica 2011 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal Proteoglycan 4 Primary Antibody für ELISA - ABIN449721 : Jay, Torres, Warman, Laderer, Breuer: The role of lubricin in the mechanical behavior of synovial fluid. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

Weitere Antikörper gegen Proteoglycan 4 Interaktionspartner

Human Proteoglycan 4 (PRG4) Interaktionspartner

  1. IL6 (zeige IL6 Antikörper) and PRG4 represent potential novel tissue biomarkers of disease severity and prognosis in conjunctival fibrosis after glaucoma surgery.

  2. adult talar cartilage increases both PRG4 release and biosynthetic activity as immediate cellular response to injury

  3. Double knockdown of PRG4 and IL-24 (zeige IL24 Antikörper) did not inhibit myxoid liposarcoma (MLS)- cell growth, and single knockdown of PRG4 remarkably increased IL-24 (zeige IL24 Antikörper) expression. These results suggest that the growth inhibitory effect of PRG4 knockdown is caused by induction of IL-24 (zeige IL24 Antikörper) expression, and PRG4 may contribute to maintain MLS cell growth through repression of IL-24 (zeige IL24 Antikörper) expression.

  4. lubricin expression may typify adaptive and neoplastic changes along a pathway toward fibroblast-like synoviocytes

  5. PRG4 binds to TLR2 (zeige TLR2 Antikörper) and TLR4 (zeige TLR4 Antikörper) and this binding mediates a novel anti-inflammatory role for PRG4.

  6. Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo

  7. PRG4 is a novel putative ligand for CD44 (zeige CD44 Antikörper) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (zeige CD44 Antikörper)-mediated mechanism.

  8. The O-glycomap of lubricin, a novel mucin (zeige SLC13A2 Antikörper) responsible for joint lubrication, has been identified by site-specific glycopeptide analysis.

  9. Lubricin (Prg4) plays a role in preventing damage to the superficial zone and preservation of chondrocytes. [Review]

  10. 5 novel PRG4 mutations and the first case of CACP syndrome resulting from uniparental disomy of chromosome 1.

Cow (Bovine) Proteoglycan 4 (PRG4) Interaktionspartner

  1. the intermolecular disulfide-bonded multimeric structure of PRG4 is important for its ability to adsorb to a cartilage surface and function as a boundary lubricant.

  2. The present investigation provides novel insights into the role of the Wnt (zeige WNT2 Antikörper) signalling pathways in SZP accumulation in synoviocytes and their roles in the homeostasis of normal joints.

  3. The important role of PRG4 in reducing friction in the tissues and compartments of the knee/stifle joint.

  4. The role of cell surface glycosaminoglycans (GAGs) during TGF-beta1 (zeige TGFB1 Antikörper) stimulation of SZP/lubricin/PRG4 in superficial zone articular chondrocytes, was investigated.

  5. Lubricin expression in explant cartilage was also suppressed under hypoxia

  6. SZP production is dependent on the functional cytoskeleton, and Rho GTPases contribute to SZP accumulation by modulating the actions of TGFbeta (zeige TGFB1 Antikörper).

  7. the combined treatment with TGF-beta1 (zeige TGFB1 Antikörper) and BMP-7 (zeige BMP7 Antikörper) or treatment first with TGF-beta1 (zeige TGFB1 Antikörper) followed by BMP-7 (zeige BMP7 Antikörper) was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.

  8. A variety of monomeric PRG4 proteins and a disulfide-bonded dimer/multimer are secreted by chondrocytes in bovine cartilage explants.

  9. proteoglycan 4 expression and chondrocyte phenotype is invluenced by matrix molecules and alginate-embedded zonal chondrocytes and mesenchymal stem cells

  10. These findings suggest a generalized approach which may be used for molecular resurfacing of tissue surfaces with PRG4 and other lubricating biomolecules.

Mouse (Murine) Proteoglycan 4 (PRG4) Interaktionspartner

  1. Data indicate that Prg4 is needed for the temporomandibular joint integrity and long-term postnatal function. In its absence, progenitor cells near presumptive articular layer and disc undergo ectopic chondrogenesis and generate ectopic cartilage, possibly driven by aberrant activation of Hh signaling.

  2. Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.

  3. Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.

  4. PRG4 is a novel putative ligand for CD44 (zeige CD44 Antikörper) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (zeige CD44 Antikörper)-mediated mechanism.

  5. Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.

  6. findings confirm the importance of lubricin in intrasynovial tendon lubrication.

  7. mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage

  8. changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading

  9. Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.

  10. lubricin has roles in boundary lubrication, and cell survival

Pig (Porcine) Proteoglycan 4 (PRG4) Interaktionspartner

  1. Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva.

Rabbit Proteoglycan 4 (PRG4) Interaktionspartner

  1. Lubricin/PRG4 gene expression was increased in medial collateral ligaments after 14 weeks of menopause in adult rabbits.

  2. The mRNA expression levels for lubricin/proteoglycan 4 (PRG4) and tissue inhibitor of metalloproteinase-3 (zeige TIMP3 Antikörper) increase with aging.

Proteoglycan 4 (PRG4) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit anti-Proteoglycan 4 (PRG4) Antikörper

  • proteoglycan 4 (PRG4) Antikörper
  • proteoglycan 4 (Prg4) Antikörper
  • proteoglycan 4b (prg4b) Antikörper
  • proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) (Prg4) Antikörper
  • bG174L6.2 Antikörper
  • CACP Antikörper
  • DOL54 Antikörper
  • HAPO Antikörper
  • JCAP Antikörper
  • lubricin Antikörper
  • MSF Antikörper
  • PRG4 Antikörper
  • si:dkey-97o5.3 Antikörper
  • SZP Antikörper
  • zgc:122988 Antikörper

Bezeichner auf Proteinebene für anti-Proteoglycan 4 (PRG4) Antikörper

articular superficial zone protein , bG174L6.2 (MSF: megakaryocyte stimulating factor ) , lubricin , megakaryocyte stimulating factor , megakaryocyte-stimulating factor , superficial zone proteoglycan , MLL septin-like fusion , proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome) , proteoglycan 4 , p53-responsive gene 4 , proteoglycan 3

GENE ID SPEZIES
10216 Homo sapiens
280867 Bos taurus
289104 Rattus norvegicus
553377 Danio rerio
768493 Gallus gallus
100034016 Equus caballus
100294585 Ovis aries
96875 Mus musculus
664716 Canis lupus familiaris
100518683 Sus scrofa
100347000 Oryctolagus cuniculus
100716004 Cavia porcellus
Ausgewählte Anbieter für anti-Proteoglycan 4 (PRG4) Antikörper
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