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PROC encodes a vitamin K-dependent plasma glycoprotein. Zusätzlich bieten wir Ihnen PROC Kits (22) und PROC Proteine (21) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 35 products:
Human Polyclonal PROC Primary Antibody für IHC (p), WB - ABIN3044486
Liu, An, Liu, Li, Tang, Chen: Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses. in Antiviral research 2015
Show all 10 Pubmed References
Data show that activated protein C signals via protease activated receptors PAR2 (zeige F2RL1 Antikörper)/PAR3 (zeige F2RL2 Antikörper) to expand Treg cells, mitigating the disease in mice.
insulin (zeige INS Antikörper) and aPC (zeige APC Antikörper) converge on a common spliced-X-box binding protein-1 (zeige XBP1 Antikörper) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (zeige FURIN Antikörper) or PC5 (zeige PCSK5 Antikörper)/6 in hepatocytes results in a approximately 30% decrease in APC (zeige APC Antikörper) levels, with no significant contribution from PACE4 (zeige PCSK6 Antikörper). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (zeige F2 Antikörper) activation.
APC (zeige APC Antikörper) modifies pulmonary fibrosis by limiting thrombin (zeige F2 Antikörper)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (zeige APOE Antikörper)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (zeige APC Antikörper)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (zeige APC Antikörper) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (zeige PROCR Antikörper)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (zeige THBD Antikörper) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (zeige PLA2G2A Antikörper)-V plays a thrombogenic role by impairing the ability of EPCR (zeige PROCR Antikörper) to promote protein C activation.
We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.
Developed functional protein S assays that measure both the activated protein C- and TFPI (zeige TFPI Antikörper)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.
Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer.
Genetically higher protein C was associated with a lower risk of ischaemic heart disease.
EPCR (zeige PROCR Antikörper) occupancy recruits G-protein coupled receptor kinase 5 (zeige GRK5 Antikörper), thereby inducing beta-arrestin-2 (zeige ARRB2 Antikörper) biased PAR1 (zeige MARK2 Antikörper) signaling by both APC (zeige APC Antikörper) and thrombin (zeige F2 Antikörper). In
A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency
Both probands had hereditary protein C deficiencies, for which their parents were all carriers.
Variants influencing circulating protein C levels in the CELSR2 (zeige CELSR2 Antikörper)-PSRC1 (zeige PSRC1 Antikörper)-SORT1 (zeige SORT1 Antikörper) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.
These findings suggest that the anti-inflammatory function of APC (zeige APC Antikörper) at therapeutic concentrations may include the inhibition of NETosis in an EPCR (zeige PROCR Antikörper)-, PAR3 (zeige F2RL2 Antikörper)-, and Mac-1 (zeige ITGAM Antikörper)-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC (zeige APC Antikörper) in disease states including sepsis.
Activated protein c is a ghrelin (zeige GHRL Antikörper) endopeptidase.
Activated protein C(APC (zeige APC Antikörper)) combined with protein S(PS) had significant antithrombotic effect. APC (zeige APC Antikörper) combined with PS prolonged clotting time. Dependence on APC (zeige APC Antikörper)-cofactor activity of PS for expression of anticoagulant activity by APC (zeige APC Antikörper).
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
, anticoagulant protein C
, vitamin K-dependent protein C
, protein C (inactivator of coagulation factors Va and VIIIa)
, vitamin K-dependent protein C-like
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, catalytic region
, protein C (precursor of vitamin K-dependent serine protease)