Porcupine Homolog (Drosophila) Proteine (PORCN)

PORCN belongs to the evolutionarily conserved porcupine (Porc) gene family. Zusätzlich bieten wir Ihnen Porcupine Homolog (Drosophila) Antikörper (26) und Porcupine Homolog (Drosophila) Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PORCN 64840 Q9H237
PORCN 53627 Q9JJJ7
Ratte PORCN PORCN 317368  
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
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PORCN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Porcupine Homolog (Drosophila) (PORCN) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Porcupine Homolog (Drosophila) (PORCN) Interaktionspartner

  1. Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls.

  2. stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum

  3. WntD, a recently characterized Drosophila Wnt family member, does not require Porcupine or Wntless/Evi/Sprinter for its secretion or signaling activity

  4. Role of the porcupine gene in the development of the wing imaginal disk of Drosophila melanogaster

Human Porcupine Homolog (Drosophila) (PORCN) Interaktionspartner

  1. Case Report: mosaicism for PORCN mutations in focal dermal hypoplasia (Goltz Syndrome).

  2. Data suggest that PORCN exhibits substrate specificity that includes a Wnt3a (zeige WNT3A Proteine) peptide fragment (residues 199-219, with disulfide bonds); recombinant PORCN containing a point mutation (R228C) associated with focal dermal hypoplasia exhibits impaired acylation activity toward Wnt3a (zeige WNT3A Proteine) peptide fragment. (PORCN = porcupine O-acyltransferase; Wnt3a (zeige WNT3A Proteine) = Wnt (zeige WNT2 Proteine) family member 3A)

  3. Inhibition of Wnt (zeige WNT2 Proteine) signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers

  4. three distinct members [porcupine (PORCN), hedgehog (zeige SHH Proteine) (Hh) acyltransferase (HHAT (zeige HHAT Proteine)) and ghrelin O-acyltransferase (zeige MBOAT4 Proteine) (GOAT)] have been shown to acylate specific proteins or peptides.

  5. porcupine-mediated production of Wnts is context dependent and is not required for all Wnts production, suggesting that alternative mechanisms exist for Wnts production.

  6. We describe the first case of non-mosaic males affected with syndromic microphthalmia because of a non-synonymous variant in the PORCN gene.

  7. the Wnt (zeige WNT2 Proteine) amino acid residues required for recognition and palmitoylation by PORCN

  8. We describe the ophthalmologic findings in an 18-month-old boy with mosaicism of a novel mutation in PORCN.

  9. a novel variant in the PORCN gene (c.1250T>C:p.F417S) in the focal dermal hypoplasia with spinal anomaly

  10. We report a typical focal dermal hypoplasia (FDH (zeige ADH5 Proteine)) patient with a recurrent PORCN mutation, which was previously identified, and a second female, with an almost unilateral FDH (zeige ADH5 Proteine) and a novel postzygotic PORCN mutation.

Mouse (Murine) Porcupine Homolog (Drosophila) (PORCN) Interaktionspartner

  1. This study showed that postnatal ablation of Porcupine in the uterine luminal epithelium alone results in the decrease in endometrial gland number; mutant females are completely infertile.

  2. Data suggest that PORCN exhibits substrate specificity that includes a Wnt3a (zeige WNT3A Proteine) peptide fragment (residues 199-219, with disulfide bonds); recombinant PORCN containing a point mutation (R228C) associated with focal dermal hypoplasia exhibits impaired acylation activity toward Wnt3a (zeige WNT3A Proteine) peptide fragment. (PORCN = porcupine O-acyltransferase; Wnt3a (zeige WNT3A Proteine) = Wnt (zeige WNT2 Proteine) family member 3A)

  3. Porcupine-dependent Wnt (zeige WNT2 Proteine) signaling, unlike previously reported, is dispensable for postnatal gland formation but is required for post-pubertal gland maintenance as well as for stromal cell proliferation.

  4. Overexpression of PORCN enhances the ability of WLS (zeige WLS Proteine) to promote WNT1 (zeige WNT1 Proteine) trafficking to the cell surface as well as secretion, but decreases the ability of WLS (zeige WLS Proteine) to activate WNT1 (zeige WNT1 Proteine) signaling in target cell.

  5. Inhibition of porcupine abrogates kidney fibrosis not only by overcoming the redundancy of individual Wnt (zeige WNT2 Proteine) isoforms but also by preventing upstream cytokine-induced Wnt (zeige WNT2 Proteine) generation.

  6. Conditional PORCN knockout mice exhibit specific changes in AMPAR expression and gating that reduce basal synaptic transmission but leave long-term potentiation intact.

  7. Porcn is required in both extraocular and neuroectodermal tissues to regulate distinct Wnt (zeige WNT2 Proteine)-dependent processes during morphogenesis of the posterior and anterior segments of the eye

  8. Residues in predicted transmembrane domain 9 within Porcupine are essential for palmitoleoylation.

  9. Data show bronchopneumonia, rhinitis, and otitis media, suggesting a potential link between Porcn function and the normal development of ciliated cells.

  10. Studies highlight the importance of Wnt3 (zeige WNT3 Proteine) and Wnt7b (zeige WNT7B Proteine) for embryonic and placental development but suggest that endogenous Porcn-dependent Wnt (zeige WNT2 Proteine) secretion does not play an essential role in either implantation or blastocyst lineage specification.

Porcupine Homolog (Drosophila) (PORCN) Protein Überblick

Protein Überblick

This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the Porc family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Genbezeichner und Symbole assoziert mit PORCN

  • porcupine (por)
  • porcupine O-acyltransferase (PORCN)
  • porcupine homolog (Drosophila) (Porcn)
  • porcupine O-acyltransferase (Porcn)
  • 15175 Protein
  • 2410004O13Rik Protein
  • AW045557 Protein
  • CG6205 Protein
  • DHOF Protein
  • Dmel\\CG6205 Protein
  • dmPorc Protein
  • DXHXS7465e Protein
  • FODH Protein
  • l(1)17Ac Protein
  • MG61 Protein
  • mMg61 Protein
  • Mporc Protein
  • Mporc-a Protein
  • Mporc-b Protein
  • Mporc-c Protein
  • Mporc-d Protein
  • poc Protein
  • PORC Protein
  • porcupine Protein
  • Ppn Protein
  • RGD1564947 Protein

Bezeichner auf Proteinebene für PORCN

CG6205-PA , CG6205-PB , CG6205-PC , por-PA , por-PB , por-PC , probable protein-cysteine N-palmitoyltransferase porcupine , protein-cysteine N-palmitoyltransferase porcupine , porcupine-A , porcupine-B , porcupine-C , porcupine-D , porcupine homolog

GENE ID SPEZIES
32818 Drosophila melanogaster
64840 Homo sapiens
480903 Canis lupus familiaris
540373 Bos taurus
53627 Mus musculus
317368 Rattus norvegicus
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