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PHC1 is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal PHC1 Primary Antibody für ICC, IF - ABIN2668352
Miyagishima, Isono, Fujimura, Iyo, Takihara, Masumoto, Vidal, Koseki: Dissociation of mammalian Polycomb-group proteins, Ring1B and Rae28/Ph1, from the chromatin correlates with configuration changes of the chromatin in mitotic and meiotic prophase. in Histochemistry and cell biology 2003
Show all 2 Pubmed References
Human Polyclonal PHC1 Primary Antibody für IP, WB - ABIN515164
Awad, Al-Dosari, Al-Yacoub, Colak, Salih, Alkuraya, Poizat: Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis. in Human molecular genetics 2013
Human Monoclonal PHC1 Primary Antibody für FACS, ELISA - ABIN1724838
Boyer, Plath, Zeitlinger, Brambrink, Medeiros, Lee, Levine, Wernig, Tajonar, Ray, Bell, Otte, Vidal, Gifford, Young, Jaenisch: Polycomb complexes repress developmental regulators in murine embryonic stem cells. in Nature 2006
These findings reveal several cellular defects in cells carrying the PHC1 mutation and highlight the role of chromatin remodeling in the pathogenesis of PM.
PcG complex 1, involving Rae28 and Cdt1 (zeige CDT1 Antikörper), supports the activity of hematopoietic stem cells by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin (zeige GMNN Antikörper)
rae28 has a crucial role in sustaining the activity of hematopoietic stem cells to maintain hematopoiesis
Gene rae28 is involved in cardiac morphogenesis (zeige XIRP1 Antikörper) through a non cardiomyocyte pathway. However, cardiomyocyte-specific overexpression of rae28 caused dilated cardiomyopathy.
The Polycomb (zeige CBX2 Antikörper)-group gene Rae28 sustains Nkx2.5/Csx (zeige NKX2-5 Antikörper) expression and is essential for cardiac morphogenesis (zeige XIRP1 Antikörper).
in vivo results clearly indicate that Polycomb (zeige CBX2 Antikörper)-group gene rae28 is indispensable for the long-term repopulating ability of HSCs
polymeric Scm (zeige DAB1 Antikörper) complexes could extend beyond the local domains of polymeric Ph complexes on chromatin, possibly playing a role in long range repression
functional overlap between Phc2 (zeige PhC2 Antikörper) and Phc1 along with a strict dose-dependent requirement during anterior-posterior (A-P) patterning
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
, polyhomeotic-like protein 1
, early development regulator 1 (homolog of polyhomeotic 1)
, early development regulatory protein 1
, early development regulator1 (homolog of polyhomeotic 1)