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Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Zusätzlich bieten wir Ihnen Pleckstrin Homology Domain Containing, Family O Member 1 Antikörper (56) und Pleckstrin Homology Domain Containing, Family O Member 1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
Showing 7 out of 7 products:
we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations.
we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.
these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.
the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.
High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.
New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL.
There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (zeige PAK1 Proteine) for neoplastic prostate cells transformation.
CKIP-1 interacts with CARMA1 (zeige CARD11 Proteine) and has an inhibitory effect on PKCtheta (zeige PRKCQ Proteine);-CBM-NF-kappaB (zeige NFKB1 Proteine) signaling.
CKIP-1 controlled Smurf1 (zeige SMURF1 Proteine) expression in colon cancer
overexpression triggers classical monocyte activation and transactivation of the TNF (zeige TNF Proteine) promoter
PD increased CKIP-1 and Nrf2 (zeige NFE2L2 Proteine) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (zeige ICAM1 Proteine)
The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (zeige MAPK8 Proteine) phosphorylation and further upregulating IRS-1 (zeige IRS1 Proteine) phosphorylation and RI.
Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (zeige ICAM1 Proteine)) and fibronectin (zeige FN1 Proteine) plus activation of Nrf2 (zeige NFE2L2 Proteine)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.
the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis
CKIP-1 is a novel inhibitor of MSC (zeige MSC Proteine)-originated adipogenesis by enhancing HDAC1 (zeige HDAC1 Proteine)-associated repression of C/EBPalpha (zeige CEBPA Proteine).
CKIP-1 interacts with TRAF6 (zeige TRAF6 Proteine), a ubiquitin ligase (zeige RNF123 Proteine) required for K63-linked ubiquitination and plasma membrane recruitment of Akt (zeige AKT1 Proteine), and terminates TRAF6 (zeige TRAF6 Proteine)-mediated Akt (zeige AKT1 Proteine) activation.
Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).
, C-Jun-binding protein
, CK2 interacting protein 1; HQ0024c protein
, CK2-interacting protein 1
, PH domain-containing family O member 1
, casein kinase 2-interacting protein 1
, osteoclast maturation-associated gene 120 protein
, pleckstrin homology domain-containing family O member 1
, pleckstrin homology domain containing, family O member 1
, CK2 interacting protein 1
, Jun zipper-associated 2
, TNF intracellular domain-interacting protein
, CK2-interacting protein-1
, PH domain-containing family O member 1-A
, pleckstrin homology domain-containing family O member 1-A