Pleckstrin Homology Domain Containing, Family O Member 1 Proteine (PLEKHO1)

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Zusätzlich bieten wir Ihnen Pleckstrin Homology Domain Containing, Family O Member 1 Antikörper (56) und Pleckstrin Homology Domain Containing, Family O Member 1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PLEKHO1 51177 Q53GL0
PLEKHO1 67220 Q9JIY0
PLEKHO1 310674 Q5BJM5
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top Pleckstrin Homology Domain Containing, Family O Member 1 Proteine auf antikoerper-online.de

Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,131.33
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,135.00
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,179.00
Details

PLEKHO1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Interaktionspartnern

Human Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Interaktionspartner

  1. we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations.

  2. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.

  3. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.

  4. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  5. High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.

  6. New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL.

  7. There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (zeige PAK1 Proteine) for neoplastic prostate cells transformation.

  8. CKIP-1 interacts with CARMA1 (zeige CARD11 Proteine) and has an inhibitory effect on PKCtheta (zeige PRKCQ Proteine);-CBM-NF-kappaB (zeige NFKB1 Proteine) signaling.

  9. CKIP-1 controlled Smurf1 (zeige SMURF1 Proteine) expression in colon cancer

  10. overexpression triggers classical monocyte activation and transactivation of the TNF (zeige TNF Proteine) promoter

Mouse (Murine) Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Interaktionspartner

  1. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.

  2. PD increased CKIP-1 and Nrf2 (zeige NFE2L2 Proteine) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (zeige ICAM1 Proteine)

  3. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.

  4. The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (zeige MAPK8 Proteine) phosphorylation and further upregulating IRS-1 (zeige IRS1 Proteine) phosphorylation and RI.

  5. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  6. Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (zeige ICAM1 Proteine)) and fibronectin (zeige FN1 Proteine) plus activation of Nrf2 (zeige NFE2L2 Proteine)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.

  7. the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis

  8. CKIP-1 is a novel inhibitor of MSC (zeige MSC Proteine)-originated adipogenesis by enhancing HDAC1 (zeige HDAC1 Proteine)-associated repression of C/EBPalpha (zeige CEBPA Proteine).

  9. CKIP-1 interacts with TRAF6 (zeige TRAF6 Proteine), a ubiquitin ligase (zeige RNF123 Proteine) required for K63-linked ubiquitination and plasma membrane recruitment of Akt (zeige AKT1 Proteine), and terminates TRAF6 (zeige TRAF6 Proteine)-mediated Akt (zeige AKT1 Proteine) activation.

  10. Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.

Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Protein Überblick

Protein Überblick

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).

Genbezeichner und Symbole assoziert mit PLEKHO1

  • pleckstrin homology domain containing O1 (PLEKHO1)
  • pleckstrin homology domain containing, family O member 1 (Plekho1)
  • pleckstrin homology domain containing O1 (Plekho1)
  • pleckstrin homology domain containing, family O member 1a (plekho1a)
  • 2810052M02Rik Protein
  • ckip-1 Protein
  • Ckip1 Protein
  • JZA-20 Protein
  • Jza2 Protein
  • OC120 Protein
  • plekho1 Protein
  • RGD1311487 Protein
  • si:dkey-200h23.2 Protein

Bezeichner auf Proteinebene für PLEKHO1

2810052M02Rik , C-Jun-binding protein , CK2 interacting protein 1; HQ0024c protein , CK2-interacting protein 1 , JBP , OC120 , PH domain-containing family O member 1 , casein kinase 2-interacting protein 1 , osteoclast maturation-associated gene 120 protein , pleckstrin homology domain-containing family O member 1 , pleckstrin homology domain containing, family O member 1 , CK2 interacting protein 1 , Jun zipper-associated 2 , TNF intracellular domain-interacting protein , CK2-interacting protein-1 , PH domain-containing family O member 1-A , pleckstrin homology domain-containing family O member 1-A

GENE ID SPEZIES
51177 Homo sapiens
426108 Gallus gallus
457268 Pan troglodytes
607927 Canis lupus familiaris
706145 Macaca mulatta
788251 Bos taurus
100152184 Sus scrofa
100347162 Oryctolagus cuniculus
100444299 Pongo abelii
67220 Mus musculus
310674 Rattus norvegicus
563283 Danio rerio
Ausgewählte Anbieter für Pleckstrin Homology Domain Containing, Family O Member 1 Proteine (PLEKHO1)
Haben Sie etwas anderes gesucht?